Vortrag im Rahmen des FAU / IZKF Gastprofessorenprogramms
Towards a Bioinstructive Design of Scaffold Biomaterials for Vocal Fold Tissue Engineering
Prof. Nicole Y.K. Li-Jessen, PhD, McGill University Montreal, Canada
Canada Research Chair (tier 2) in Personalized Medicine of Voice Disorders
Assistant Professor, School of Communication Sciences and Disorders
Associate Member, Departments of Otolaryngology and Biomedical Engineering
Patients with recalcitrant chronic voice disorders often suffer from fibrotic or atrophic changes in their vocal fold (VF) mucosae that impair the oscillation of VF for phonatory functions. Tissue engineering-based strategies are harnessed for defected VF replacement or regeneration through the delivery of cells, bioactive molecules and/or supporting scaffolds. Most laboratories focus on fabricating the biomaterials as complex as possible to recapitulate the native microstructure of the organ. However, an over-engineering materials may also impede the innate processes of cells and tissues. Our laboratory is interested in taking a different perspective.
Our plan is to engineer inductive biomaterials that can effectively modulate the innate immune system and induce a pro-regenerative environment for the cells to rebuild the injured tissues. At the same time, the sheer amount of possible material options are unbounded. Any slight variations in the property of the material could result in notable difference in cell response. To mitigate this obstacle, we leverage our experience in biological computing to help guide the rational design of VF scaffold biomaterials. The Food and Drug Administration in the United States had recently planned to incorporate computational modeling and simulation as part of the regulatory approval process of drugs and medical products including tissue engineered materials. In this talk, I will present our approach towards the development of bioinstructive biomaterials for vocal fold repair using an integrated empirical and computational approach.
Hierzu lade ich herzlich ein.
Prof. Dr. M. Döllinger