{"id":6899,"date":"2023-04-28T13:43:23","date_gmt":"2023-04-28T11:43:23","guid":{"rendered":"https:\/\/www.izkf.med.fau.de\/?page_id=6899"},"modified":"2025-10-22T17:23:07","modified_gmt":"2025-10-22T15:23:07","slug":"neurowissenschaften","status":"publish","type":"page","link":"https:\/\/www.izkf.med.fau.de\/en\/projekte\/erstantragsteller-projekte\/1582-2\/neurowissenschaften\/","title":{"rendered":"Neurosciences"},"content":{"rendered":"<div class=\"wp-block-rrze-elements-collapsibles \"><div class=\"accordion\">\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"j95-franziska-thiele-institute-of-biochemistry-role-of-tip60-in-the-pns\" data-href=\"#j95-franziska-thiele-institute-of-biochemistry-role-of-tip60-in-the-pns\" type=\"button\" aria-expanded=\"false\" aria-controls=\"j95-franziska-thiele-institute-of-biochemistry-role-of-tip60-in-the-pns-section\" id=\"j95-franziska-thiele-institute-of-biochemistry-role-of-tip60-in-the-pns\">J95: Franziska Thiele, Institute of Biochemistry | Role of Tip60 in the PNS<\/button><\/h2><div id=\"j95-franziska-thiele-institute-of-biochemistry-role-of-tip60-in-the-pns-section\" class=\"accordion-body \" aria-labelledby=\"j95-franziska-thiele-institute-of-biochemistry-role-of-tip60-in-the-pns\" role=\"region\" name=\"j95-franziska-thiele-institute-of-biochemistry-role-of-tip60-in-the-pns\"><div class=\"accordion-inner clearfix\">\n\n<p><strong>Main Research: Neurosciences<\/strong> <\/p>\n\n\n\n<p>Term: 01.01.2022 &#8211; 30.09.2025 <\/p>\n\n\n\n<p>Proper Schwann cell development and myelination are essential for a functional peripheral nervous system and regulated by networks of chromatin modifiers and transcription factors. Here I plan to study the role of the acetyltransferase Tip60 as part of the Tip60\/Ep400 chromatin remodeling complex in lineage progression and myelination by characterizing its target genes and interaction with transcription factor Sox10. Results may help to better understand peripheral neuropathies. <\/p>\n\n\n\n<p><strong>Contact:<br><\/strong>Dr. rer. nat. Franziska Thiele<br>Institute of Biochemistry<br><u>email:&nbsp; <a href=\"mailto:franziska.thiele@fau.de\">franziska.thiele@fau.de<\/a><\/u><\/p>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"j109-fanni-annamaria-boros-department-of-molecular-neurology-extracellular-vesicles-in-parkinsons-disease\" data-href=\"#j109-fanni-annamaria-boros-department-of-molecular-neurology-extracellular-vesicles-in-parkinsons-disease\" type=\"button\" aria-expanded=\"false\" aria-controls=\"j109-fanni-annamaria-boros-department-of-molecular-neurology-extracellular-vesicles-in-parkinsons-disease-section\" id=\"j109-fanni-annamaria-boros-department-of-molecular-neurology-extracellular-vesicles-in-parkinsons-disease\">J109: Fanni Annamaria Boros, Department of Molecular Neurology | Extracellular vesicles in Parkinson\u2019s disease<\/button><\/h2><div id=\"j109-fanni-annamaria-boros-department-of-molecular-neurology-extracellular-vesicles-in-parkinsons-disease-section\" class=\"accordion-body \" aria-labelledby=\"j109-fanni-annamaria-boros-department-of-molecular-neurology-extracellular-vesicles-in-parkinsons-disease\" role=\"region\" name=\"j109-fanni-annamaria-boros-department-of-molecular-neurology-extracellular-vesicles-in-parkinsons-disease\"><div class=\"accordion-inner clearfix\">\n\n<p><strong>Main Research: Neurosciences<\/strong> <\/p>\n\n\n\n<p>Term: 01.01.2024 &#8211; 30.06.2026 <\/p>\n\n\n\n<p>The aim of this project is to facilitate the understanding of the role of extracellular vesicles (EVs) in the development and progression of Parkinson\u2019s disease (PD). EVs extracted from blood of PD patients and controls will be fractionated according to cellular origin and cargo profiling will be performed focusing on pathogenic forms of aSyn and regulatory RNAs. The results will offer deeper insights in PD-related signatures, and permit exploring the origin and transfer of pathogenic molecules. <\/p>\n\n\n\n<div class=\"fau-person thumb-size-small border\" itemscope itemtype=\"http:\/\/schema.org\/Person\">\n<div class=\"row\"><figure itemprop=\"image\" class=\"person-thumb\" aria-hidden=\"true\" role=\"presentation\" itemtype=\"http:\/\/schema.org\/ImageObject\"><a href=\"https:\/\/www.izkf.med.fau.de\/person\/fanni-annamaria-boros\/\" tabindex=\"-1\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2024\/02\/Boros-F-e1707997862152-120x160.png\" itemprop=\"contentUrl\" alt=\"Fanni Annamaria Boros\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2024\/02\/Boros-F-e1707997862152-120x160.png 120w, https:\/\/www.izkf.med.fau.de\/files\/2024\/02\/Boros-F-e1707997862152-240x320.png 240w\"><\/a><meta itemprop=\"identifier\" content=\"https:\/\/www.izkf.med.fau.de\/person\/fanni-annamaria-boros\/\"><meta itemprop=\"width\" content=\"120\"><meta itemprop=\"height\" content=\"160\"><\/figure><div class=\"person-default-thumb\"><h3><a href=\"https:\/\/www.izkf.med.fau.de\/person\/fanni-annamaria-boros\/\"><span itemprop=\"name\"><span itemprop=\"honorificPrefix\">Dr.<\/span> <span class=\"fullname\"><span itemprop=\"givenName\">Fanni Annamaria<\/span> <span itemprop=\"familyName\">Boros<\/span><\/span><\/span><\/a><\/h3><div class=\"person-info\"><p itemprop=\"worksFor\" itemtype=\"http:\/\/schema.org\/Organization\"><span itemprop=\"name\">Molekular-Neurologische Abteilung<\/span><br><\/p><ul class=\"contactlist\"><li class=\"person-info-email email\"><span class=\"screen-reader-text\">E-Mail: <\/span><a itemprop=\"email\" href=\"mailto:fanniannamaria.boros@uk-erlangen.de\">fanniannamaria.boros@uk-erlangen.de<\/a><\/li><\/ul><\/div><\/div><\/div><\/div>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"j111-alexander-german-department-of-molecular-neurology-voxelomic-atlas\" data-href=\"#j111-alexander-german-department-of-molecular-neurology-voxelomic-atlas\" type=\"button\" aria-expanded=\"false\" aria-controls=\"j111-alexander-german-department-of-molecular-neurology-voxelomic-atlas-section\" id=\"j111-alexander-german-department-of-molecular-neurology-voxelomic-atlas\">J111: Alexander German, Department of Molecular Neurology | Voxelomic Atlas<\/button><\/h2><div id=\"j111-alexander-german-department-of-molecular-neurology-voxelomic-atlas-section\" class=\"accordion-body \" aria-labelledby=\"j111-alexander-german-department-of-molecular-neurology-voxelomic-atlas\" role=\"region\" name=\"j111-alexander-german-department-of-molecular-neurology-voxelomic-atlas\"><div class=\"accordion-inner clearfix\">\n\n<p><strong>Main Research: Neurosciences<\/strong> <\/p>\n\n\n\n<p>Term: 01.10.2024 &#8211; 31.12.2026 <\/p>\n\n\n\n<p>We aim to develop a voxelomic atlas of the brain. We will leverage high-resolution, multi-spectral ex-vivo imaging data from Magnetic Resonance Imaging (MRI) in combination with deep learning techniques, to compare single-voxel data between individuals. The atlas will serve as a tool to interpret single-voxel neuroanatomical variability. The project will build on preliminary work in sample preparation and data processing techniques. <\/p>\n\n\n\n<div class=\"fau-person thumb-size-small border\" itemscope itemtype=\"http:\/\/schema.org\/Person\">\n<div class=\"row\"><figure itemprop=\"image\" class=\"person-thumb\" aria-hidden=\"true\" role=\"presentation\" itemtype=\"http:\/\/schema.org\/ImageObject\"><a href=\"https:\/\/www.izkf.med.fau.de\/person\/alexander-german\/\" tabindex=\"-1\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2024\/05\/German-120x160.jpg\" itemprop=\"contentUrl\" alt=\"Alexander German\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2024\/05\/German-120x160.jpg 120w, https:\/\/www.izkf.med.fau.de\/files\/2024\/05\/German-240x320.jpg 240w\"><\/a><meta itemprop=\"identifier\" content=\"https:\/\/www.izkf.med.fau.de\/person\/alexander-german\/\"><meta itemprop=\"width\" content=\"120\"><meta itemprop=\"height\" content=\"160\"><\/figure><div class=\"person-default-thumb\"><h3><a href=\"https:\/\/www.izkf.med.fau.de\/person\/alexander-german\/\"><span itemprop=\"name\"><span itemprop=\"honorificPrefix\">Dr.<\/span> <span class=\"fullname\"><span itemprop=\"givenName\">Alexander<\/span> <span itemprop=\"familyName\">German<\/span><\/span><\/span><\/a><\/h3><div class=\"person-info\"><p itemprop=\"worksFor\" itemtype=\"http:\/\/schema.org\/Organization\"><span itemprop=\"department\">Molekular-Neurologische Abteilung<\/span><br><\/p><ul class=\"contactlist\"><li class=\"person-info-email email\"><span class=\"screen-reader-text\">E-Mail: <\/span><a itemprop=\"email\" href=\"mailto:alexander.german@uk-erlangen.de\">alexander.german@uk-erlangen.de<\/a><\/li><\/ul><\/div><\/div><\/div><\/div>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"j112-daniil-kachkin-department-of-stem-cell-biology-lysosomal-and-protein-dysregulation-in-spg11\" data-href=\"#j112-daniil-kachkin-department-of-stem-cell-biology-lysosomal-and-protein-dysregulation-in-spg11\" type=\"button\" aria-expanded=\"false\" aria-controls=\"j112-daniil-kachkin-department-of-stem-cell-biology-lysosomal-and-protein-dysregulation-in-spg11-section\" id=\"j112-daniil-kachkin-department-of-stem-cell-biology-lysosomal-and-protein-dysregulation-in-spg11\">J112: Daniil Kachkin, Department of Stem Cell Biology | Lysosomal and protein dysregulation in SPG11<\/button><\/h2><div id=\"j112-daniil-kachkin-department-of-stem-cell-biology-lysosomal-and-protein-dysregulation-in-spg11-section\" class=\"accordion-body \" aria-labelledby=\"j112-daniil-kachkin-department-of-stem-cell-biology-lysosomal-and-protein-dysregulation-in-spg11\" role=\"region\" name=\"j112-daniil-kachkin-department-of-stem-cell-biology-lysosomal-and-protein-dysregulation-in-spg11\"><div class=\"accordion-inner clearfix\">\n\n<p><strong>Main Research: Neurosciences<\/strong> <\/p>\n\n\n\n<p>Term: 01.06.2024 &#8211; 30.11.2026 <\/p>\n\n\n\n<p>Loss of spatacsin protein leads to the development of SPG11-HSP disorder. It has a rapid progression and exhibits various neurological symptoms, like Parkinsonism, and is characterized by dysregulated glycosphingolipid metabolism. The research examines the connection between SPG11 depletion, lysosomal glycosphingolipid degradation pathway and protein aggregation. <\/p>\n\n\n\n<div class=\"fau-person thumb-size-small border\" itemscope itemtype=\"http:\/\/schema.org\/Person\">\n<div class=\"row\"><figure itemprop=\"image\" class=\"person-thumb\" aria-hidden=\"true\" role=\"presentation\" itemtype=\"http:\/\/schema.org\/ImageObject\"><a href=\"https:\/\/www.izkf.med.fau.de\/person\/daniil-kachkin\/\" tabindex=\"-1\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2024\/04\/Kachkin-120x160.jpg\" itemprop=\"contentUrl\" alt=\"Daniil Kachkin\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2024\/04\/Kachkin-120x160.jpg 120w, https:\/\/www.izkf.med.fau.de\/files\/2024\/04\/Kachkin-240x320.jpg 240w\"><\/a><meta itemprop=\"identifier\" content=\"https:\/\/www.izkf.med.fau.de\/person\/daniil-kachkin\/\"><meta itemprop=\"width\" content=\"120\"><meta itemprop=\"height\" content=\"160\"><\/figure><div class=\"person-default-thumb\"><h3><a href=\"https:\/\/www.izkf.med.fau.de\/person\/daniil-kachkin\/\"><span itemprop=\"name\"><span itemprop=\"honorificPrefix\">Dr.<\/span> <span class=\"fullname\"><span itemprop=\"givenName\">Daniil<\/span> <span itemprop=\"familyName\">Kachkin<\/span><\/span><\/span><\/a><\/h3><div class=\"person-info\"><p itemprop=\"worksFor\" itemtype=\"http:\/\/schema.org\/Organization\"><span itemprop=\"name\">Stammzellbiologische Abteilung<\/span><br><\/p><ul class=\"contactlist\"><li class=\"person-info-email email\"><span class=\"screen-reader-text\">E-Mail: <\/span><a itemprop=\"email\" href=\"mailto:daniil.kachkin@uk-erlangen.de\">daniil.kachkin@uk-erlangen.de<\/a><\/li><\/ul><\/div><\/div><\/div><\/div>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"j121-tim-aberle-institute-of-biochemistry-the-role-of-casr-in-oligodendrocyte-development\" data-href=\"#j121-tim-aberle-institute-of-biochemistry-the-role-of-casr-in-oligodendrocyte-development\" type=\"button\" aria-expanded=\"false\" aria-controls=\"j121-tim-aberle-institute-of-biochemistry-the-role-of-casr-in-oligodendrocyte-development-section\" id=\"j121-tim-aberle-institute-of-biochemistry-the-role-of-casr-in-oligodendrocyte-development\">J121: Tim Aberle, Institute of Biochemistry | The role of Casr in oligodendrocyte development<\/button><\/h2><div id=\"j121-tim-aberle-institute-of-biochemistry-the-role-of-casr-in-oligodendrocyte-development-section\" class=\"accordion-body \" aria-labelledby=\"j121-tim-aberle-institute-of-biochemistry-the-role-of-casr-in-oligodendrocyte-development\" role=\"region\" name=\"j121-tim-aberle-institute-of-biochemistry-the-role-of-casr-in-oligodendrocyte-development\"><div class=\"accordion-inner clearfix\">\n\n<p><strong>Main Research: Neurosciences<\/strong> <\/p>\n\n\n\n<p>Term: 01.11.2025 &#8211; 30.04.2028<\/p>\n\n\n\n<p>Casr is a G-protein coupled sensor for extracellular Ca2+ with selective CNS expression in differentiating oligodendrocytes (OL). I aim to determine role, targets, signaling, and regulation of Casr in differentiating OL during developmental myelination and remyelination using genetic and pharmacological in vivo, ex vivo, and in vitro approaches, and thereby identify Casr as a major mediator of Ca2+ effects on OL differentiation and as a therapeutic target in myelin-associated diseases. <\/p>\n\n\n\n<div class=\"fau-person thumb-size-small border\" itemscope itemtype=\"http:\/\/schema.org\/Person\">\n<div class=\"row\"><figure itemprop=\"image\" class=\"person-thumb\" aria-hidden=\"true\" role=\"presentation\" itemtype=\"http:\/\/schema.org\/ImageObject\"><a href=\"https:\/\/www.izkf.med.fau.de\/person\/tim-aberle\/\" tabindex=\"-1\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2025\/07\/Aberle-120x160.jpg\" itemprop=\"contentUrl\" alt=\"Tim Aberle\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2025\/07\/Aberle-120x160.jpg 120w, https:\/\/www.izkf.med.fau.de\/files\/2025\/07\/Aberle-225x300.jpg 225w, https:\/\/www.izkf.med.fau.de\/files\/2025\/07\/Aberle-240x320.jpg 240w, https:\/\/www.izkf.med.fau.de\/files\/2025\/07\/Aberle-45x60.jpg 45w, https:\/\/www.izkf.med.fau.de\/files\/2025\/07\/Aberle-180x240.jpg 180w, https:\/\/www.izkf.med.fau.de\/files\/2025\/07\/Aberle-353x470.jpg 353w, https:\/\/www.izkf.med.fau.de\/files\/2025\/07\/Aberle.jpg 719w\"><\/a><meta itemprop=\"identifier\" content=\"https:\/\/www.izkf.med.fau.de\/person\/tim-aberle\/\"><meta itemprop=\"width\" content=\"120\"><meta itemprop=\"height\" content=\"160\"><\/figure><div class=\"person-default-thumb\"><h3><a href=\"https:\/\/www.izkf.med.fau.de\/person\/tim-aberle\/\"><span itemprop=\"name\"><span itemprop=\"honorificPrefix\">Dr.<\/span> <span class=\"fullname\"><span itemprop=\"givenName\">Tim<\/span> <span itemprop=\"familyName\">Aberle<\/span><\/span><\/span><\/a><\/h3><div class=\"person-info\"><p itemprop=\"worksFor\" itemtype=\"http:\/\/schema.org\/Organization\"><span itemprop=\"name\">Institut f\u00fcr Biochemie<\/span><br><\/p><ul class=\"contactlist\"><li class=\"person-info-email email\"><span class=\"screen-reader-text\">E-Mail: <\/span><a itemprop=\"email\" href=\"mailto:tim.aberle@fau.de\">tim.aberle@fau.de<\/a><\/li><\/ul><\/div><\/div><\/div><\/div>\n\n<\/div><\/div><\/div><\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1355,"featured_media":0,"parent":6891,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"page-templates\/page-subnav.php","meta":{"_rrze_cache":"enabled","_access_permission":"","_rrze_multilang_single_locale":"en_GB","_rrze_multilang_single_source":"https:\/\/www.izkf.med.fau.de\/?page_id=3232","footnotes":""},"page_category":[154],"page_tag":[],"workflow_usergroup":[],"class_list":["post-6899","page","type-page","status-publish","hentry","page_category-general","en-GB"],"_links":{"self":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/6899","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/users\/1355"}],"replies":[{"embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/comments?post=6899"}],"version-history":[{"count":10,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/6899\/revisions"}],"predecessor-version":[{"id":114496,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/6899\/revisions\/114496"}],"up":[{"embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/6891"}],"wp:attachment":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/media?parent=6899"}],"wp:term":[{"taxonomy":"page_category","embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/page_category?post=6899"},{"taxonomy":"page_tag","embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/page_tag?post=6899"},{"taxonomy":"workflow_usergroup","embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/workflow_usergroup?post=6899"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}