{"id":6811,"date":"2023-04-24T17:18:45","date_gmt":"2023-04-24T15:18:45","guid":{"rendered":"https:\/\/www.izkf.med.fau.de\/?page_id=6811"},"modified":"2026-04-20T13:23:27","modified_gmt":"2026-04-20T11:23:27","slug":"neurowissenschaften","status":"publish","type":"page","link":"https:\/\/www.izkf.med.fau.de\/en\/projekte\/advancedprojects\/currentprojects\/neurowissenschaften\/","title":{"rendered":"Neuroscience"},"content":{"rendered":"<div class=\"wp-block-rrze-elements-collapsibles \"><div class=\"accordion\">\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"e32-sven-falk-institute-of-biochemistry-molecular-nexuses-in-neurodevelopmental-diseases\" data-href=\"#e32-sven-falk-institute-of-biochemistry-molecular-nexuses-in-neurodevelopmental-diseases\" type=\"button\" aria-expanded=\"false\" aria-controls=\"e32-sven-falk-institute-of-biochemistry-molecular-nexuses-in-neurodevelopmental-diseases-section\" id=\"e32-sven-falk-institute-of-biochemistry-molecular-nexuses-in-neurodevelopmental-diseases\">E32: Sven Falk, Institute of Biochemistry | Molecular nexuses in neurodevelopmental diseases<\/button><\/h2><div id=\"e32-sven-falk-institute-of-biochemistry-molecular-nexuses-in-neurodevelopmental-diseases-section\" class=\"accordion-body \" aria-labelledby=\"e32-sven-falk-institute-of-biochemistry-molecular-nexuses-in-neurodevelopmental-diseases\" role=\"region\" name=\"e32-sven-falk-institute-of-biochemistry-molecular-nexuses-in-neurodevelopmental-diseases\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.07.2023 &#8211; 30.06.2026 <\/p>\n\n\n\n<p>The development of a functional central nervous system depends on the accurate coordination of the highly dynamic microtubule cytoskeleton. Here we propose to chart the molecular landscape induced by mutations in microtubule cytoskeleton components implicated in neurodevelopmental disorders in human brain organoids to uncover unifying and diverging molecular features in a tissue-like context to design strategies to interfere with disease-phenotype progression.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6305\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/falk-250x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/falk-250x300.jpg 250w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/falk-853x1024.jpg 853w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/falk-768x922.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/falk-1280x1536.jpg 1280w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/falk-50x60.jpg 50w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/falk-92x110.jpg 92w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/falk-200x240.jpg 200w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/falk-267x320.jpg 267w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/falk-392x470.jpg 392w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/falk.jpg 1548w\" \/><\/figure><\/td><\/tr><tr><td><strong>Principal Investigator<\/strong><br>Dr. Sven Falk<br>E-Mail: sven.falk@fau.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"e33-melanie-kuespert-institute-of-biochemistry-deubiquitinase-otud7b-in-cns-myelination\" data-href=\"#e33-melanie-kuespert-institute-of-biochemistry-deubiquitinase-otud7b-in-cns-myelination\" type=\"button\" aria-expanded=\"false\" aria-controls=\"e33-melanie-kuespert-institute-of-biochemistry-deubiquitinase-otud7b-in-cns-myelination-section\" id=\"e33-melanie-kuespert-institute-of-biochemistry-deubiquitinase-otud7b-in-cns-myelination\">E33: Melanie K\u00fcspert, Institute of Biochemistry | Deubiquitinase Otud7b in CNS myelination<\/button><\/h2><div id=\"e33-melanie-kuespert-institute-of-biochemistry-deubiquitinase-otud7b-in-cns-myelination-section\" class=\"accordion-body \" aria-labelledby=\"e33-melanie-kuespert-institute-of-biochemistry-deubiquitinase-otud7b-in-cns-myelination\" role=\"region\" name=\"e33-melanie-kuespert-institute-of-biochemistry-deubiquitinase-otud7b-in-cns-myelination\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.07.2023 &#8211; 30.06.2026<\/p>\n\n\n\n<p>Specific regulation of protein degradation by the ubiquitin-proteasome system plays important roles in myelination, remyelination and neurodegenerative diseases. I want to analyse the functions of the deubiquitinase Otud7b in oligodendrocytes in vitro and in vivo in an oligodendrocyte-specific Otud7b knockout mouse model and identify functional targets of Otud7b in oligodendrocytes to deepen the understanding of posttranscriptional regulatory events during OL differentiation and CNS myelination.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6306\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Kuespert-250x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Kuespert-250x300.jpg 250w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Kuespert-853x1024.jpg 853w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Kuespert-768x922.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Kuespert-1280x1536.jpg 1280w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Kuespert-50x60.jpg 50w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Kuespert-92x110.jpg 92w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Kuespert-200x240.jpg 200w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Kuespert-267x320.jpg 267w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Kuespert-392x470.jpg 392w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Kuespert.jpg 1493w\" \/><\/figure><\/td><\/tr><tr><td><strong>Principal Investigator<\/strong><br>Dr. Melanie K\u00fcspert<br>E-Mail: melanie.kuespert@fau.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"e34-dieter-chichung-lie-institute-of-biochemistry-kristian-franze-institute-of-medical-physics-regulation-of-the-adult-cns-stem-cell-niche\" data-href=\"#e34-dieter-chichung-lie-institute-of-biochemistry-kristian-franze-institute-of-medical-physics-regulation-of-the-adult-cns-stem-cell-niche\" type=\"button\" aria-expanded=\"false\" aria-controls=\"e34-dieter-chichung-lie-institute-of-biochemistry-kristian-franze-institute-of-medical-physics-regulation-of-the-adult-cns-stem-cell-niche-section\" id=\"e34-dieter-chichung-lie-institute-of-biochemistry-kristian-franze-institute-of-medical-physics-regulation-of-the-adult-cns-stem-cell-niche\">E34: Dieter Chichung Lie, Institute of Biochemistry | Kristian Franze, Institute of Medical Physics | Regulation of the adult CNS stem cell niche<\/button><\/h2><div id=\"e34-dieter-chichung-lie-institute-of-biochemistry-kristian-franze-institute-of-medical-physics-regulation-of-the-adult-cns-stem-cell-niche-section\" class=\"accordion-body \" aria-labelledby=\"e34-dieter-chichung-lie-institute-of-biochemistry-kristian-franze-institute-of-medical-physics-regulation-of-the-adult-cns-stem-cell-niche\" role=\"region\" name=\"e34-dieter-chichung-lie-institute-of-biochemistry-kristian-franze-institute-of-medical-physics-regulation-of-the-adult-cns-stem-cell-niche\"><div class=\"accordion-inner clearfix\">\n\n<p>An adverse local environment (&#8220;niche&#8221;) impairs the activity of neural stem cells (NSCs) in the adult brain. We investigate the new hypothesis that NSCs play an active role in generating favorable and adverse niche conditions. Specifically, we will investigate how dysfunctional NSCs generate adverse niche conditions focusing i) on the composition and the biomechanical properties of the extracellular matrix and ii) on NSC-derived exosomes and their composition.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6308\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Lie-250x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Lie-250x300.jpg 250w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Lie-853x1024.jpg 853w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Lie-768x922.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Lie-1280x1536.jpg 1280w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Lie-1707x2048.jpg 1707w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Lie-50x60.jpg 50w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Lie-92x110.jpg 92w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Lie-200x240.jpg 200w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Lie-267x320.jpg 267w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Lie-392x470.jpg 392w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Lie.jpg 1744w\" \/><\/figure><\/td><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6194\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2022\/12\/franze-250x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2022\/12\/franze-250x300.jpg 250w, https:\/\/www.izkf.med.fau.de\/files\/2022\/12\/franze-854x1024.jpg 854w, https:\/\/www.izkf.med.fau.de\/files\/2022\/12\/franze-768x921.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2022\/12\/franze-1280x1536.jpg 1280w, https:\/\/www.izkf.med.fau.de\/files\/2022\/12\/franze-1707x2048.jpg 1707w, https:\/\/www.izkf.med.fau.de\/files\/2022\/12\/franze-50x60.jpg 50w, https:\/\/www.izkf.med.fau.de\/files\/2022\/12\/franze-92x110.jpg 92w, https:\/\/www.izkf.med.fau.de\/files\/2022\/12\/franze-200x240.jpg 200w, https:\/\/www.izkf.med.fau.de\/files\/2022\/12\/franze-267x320.jpg 267w, https:\/\/www.izkf.med.fau.de\/files\/2022\/12\/franze-392x470.jpg 392w, https:\/\/www.izkf.med.fau.de\/files\/2022\/12\/franze.jpg 1713w\" \/><\/figure><\/td><\/tr><tr><td><strong>Principal Investigator<\/strong><br>Prof. Dr. Dieter Chichung Lie<br>E-Mail: chi.lie@fau.de<\/td><td><strong>Principal Investigator<br><\/strong>Prof. Dr. Kristian Franze<br>E-Mail: kristian.franze@fau.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"e35-andr-reis-institute-of-human-genetics-peter-soba-institute-of-physiology-and-pathophysiology-deciphering-recessive-ndds\" data-href=\"#e35-andr-reis-institute-of-human-genetics-peter-soba-institute-of-physiology-and-pathophysiology-deciphering-recessive-ndds\" type=\"button\" aria-expanded=\"false\" aria-controls=\"e35-andr-reis-institute-of-human-genetics-peter-soba-institute-of-physiology-and-pathophysiology-deciphering-recessive-ndds-section\" id=\"e35-andr-reis-institute-of-human-genetics-peter-soba-institute-of-physiology-and-pathophysiology-deciphering-recessive-ndds\">E35: Andr\u00e9 Reis, Institute of Human Genetics | Peter Soba, Institute of Physiology and Pathophysiology | Deciphering recessive NDDs<\/button><\/h2><div id=\"e35-andr-reis-institute-of-human-genetics-peter-soba-institute-of-physiology-and-pathophysiology-deciphering-recessive-ndds-section\" class=\"accordion-body \" aria-labelledby=\"e35-andr-reis-institute-of-human-genetics-peter-soba-institute-of-physiology-and-pathophysiology-deciphering-recessive-ndds\" role=\"region\" name=\"e35-andr-reis-institute-of-human-genetics-peter-soba-institute-of-physiology-and-pathophysiology-deciphering-recessive-ndds\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.04.2023 &#8211; 30.04.2026<\/p>\n\n\n\n<p>Autosomal recessive mutations significantly contribute to intellectual disability and neurodevelopmental disorders (NDDs). However, high genetic heterogeneity of NDDs makes it difficult to prove pathogenicity. Using a comprehensive approach, we will combine genome sequencing and transcriptomics in a unique patient cohort of consanguineous Turkish families with at least two affected children, together with in silico analysis of candidates and in vivo screening in the Drosophila model organism.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6307\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Reis-250x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Reis-250x300.jpg 250w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Reis-853x1024.jpg 853w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Reis-768x922.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Reis-1280x1536.jpg 1280w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Reis-50x60.jpg 50w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Reis-92x110.jpg 92w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Reis-200x240.jpg 200w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Reis-267x320.jpg 267w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Reis-392x470.jpg 392w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Reis.jpg 1564w\" \/><\/figure><\/td><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6309\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Soba-250x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Soba-250x300.jpg 250w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Soba-854x1024.jpg 854w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Soba-768x921.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Soba-1280x1536.jpg 1280w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Soba-50x60.jpg 50w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Soba-92x110.jpg 92w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Soba-200x240.jpg 200w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Soba-267x320.jpg 267w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Soba-392x470.jpg 392w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Soba.jpg 1502w\" \/><\/figure><\/td><\/tr><tr><td><strong>Principal Investigator<\/strong><br>Prof. Dr. Andr\u00e9 Reis<br>E-Mail: andre.reis@uk-erlangen.de<\/td><td><strong>Principal Investigator<br><\/strong>Prof. Dr. Peter Soba<br>E-Mail: peter.soba@fau.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"e36-andreas-sagner-institute-of-biochemistry-temporal-patterning-of-dopaminergic-neurons\" data-href=\"#e36-andreas-sagner-institute-of-biochemistry-temporal-patterning-of-dopaminergic-neurons\" type=\"button\" aria-expanded=\"false\" aria-controls=\"e36-andreas-sagner-institute-of-biochemistry-temporal-patterning-of-dopaminergic-neurons-section\" id=\"e36-andreas-sagner-institute-of-biochemistry-temporal-patterning-of-dopaminergic-neurons\">E36: Andreas Sagner, Institute of Biochemistry | Temporal patterning of dopaminergic neurons<\/button><\/h2><div id=\"e36-andreas-sagner-institute-of-biochemistry-temporal-patterning-of-dopaminergic-neurons-section\" class=\"accordion-body \" aria-labelledby=\"e36-andreas-sagner-institute-of-biochemistry-temporal-patterning-of-dopaminergic-neurons\" role=\"region\" name=\"e36-andreas-sagner-institute-of-biochemistry-temporal-patterning-of-dopaminergic-neurons\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.06.2023 &#8211; 30.06.2026<\/p>\n\n\n\n<p>Parkinson\u2019s disease is a neurodegenerative movement disorder characterized by the progressive loss of midbrain dopaminergic (mDA) neurons. mDA neurons can be partitioned into numerous molecularly and functionally distinct neuronal subtypes. The molecular mechanisms orchestrating mDA neuron subtype specification are still largely unclear. This project will test the hypothesis that a temporal patterning program I recently uncovered contributes to the establishment of mDA neuron diversity.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6310\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/sagner-250x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/sagner-250x300.jpg 250w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/sagner-853x1024.jpg 853w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/sagner-768x922.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/sagner-1280x1536.jpg 1280w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/sagner-50x60.jpg 50w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/sagner-92x110.jpg 92w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/sagner-200x240.jpg 200w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/sagner-267x320.jpg 267w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/sagner-392x470.jpg 392w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/sagner.jpg 1438w\" \/><\/figure><\/td><\/tr><tr><td><strong>Principal Investigator<\/strong><br>Dr. Andreas Sagner<br>E-Mail: andreas.sagner@fau.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"e37-michael-wegner-institute-of-biochemistry-anna-fejtova-department-of-psychiatry-and-psychotherapy-ctbp1-oligodendrocytes-amp-myelination\" data-href=\"#e37-michael-wegner-institute-of-biochemistry-anna-fejtova-department-of-psychiatry-and-psychotherapy-ctbp1-oligodendrocytes-amp-myelination\" type=\"button\" aria-expanded=\"false\" aria-controls=\"e37-michael-wegner-institute-of-biochemistry-anna-fejtova-department-of-psychiatry-and-psychotherapy-ctbp1-oligodendrocytes-amp-myelination-section\" id=\"e37-michael-wegner-institute-of-biochemistry-anna-fejtova-department-of-psychiatry-and-psychotherapy-ctbp1-oligodendrocytes-amp-myelination\">E37: Michael Wegner, Institute of Biochemistry | Anna Fejtova, Department of Psychiatry and Psychotherapy | CtBP1, oligodendrocytes &amp; myelination<\/button><\/h2><div id=\"e37-michael-wegner-institute-of-biochemistry-anna-fejtova-department-of-psychiatry-and-psychotherapy-ctbp1-oligodendrocytes-amp-myelination-section\" class=\"accordion-body \" aria-labelledby=\"e37-michael-wegner-institute-of-biochemistry-anna-fejtova-department-of-psychiatry-and-psychotherapy-ctbp1-oligodendrocytes-amp-myelination\" role=\"region\" name=\"e37-michael-wegner-institute-of-biochemistry-anna-fejtova-department-of-psychiatry-and-psychotherapy-ctbp1-oligodendrocytes-amp-myelination\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.02.23 &#8211; 30.06.2026<\/p>\n\n\n\n<p>Mutations in transcriptional corepressor CtBP1 cause the neurodevelopmental disorder HADDTS. Functional CtBP1 studies in the central nervous system so far focused on neurons. We recently found that CtBP1 is also important in oligodendrocytes. Here we will characterize the oligodendroglial functions of CtBP1 and the underlying cellular and molecular mechanisms in mice and a human ES cell-derived cellular disease model to show that defects in oligodendrogenesis and myelination contribute to HADDTS<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-801\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2017\/10\/Wegner-e1579173572333-225x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2017\/10\/Wegner-e1579173572333-225x300.jpg 225w, https:\/\/www.izkf.med.fau.de\/files\/2017\/10\/Wegner-e1579173572333-60x80.jpg 60w, https:\/\/www.izkf.med.fau.de\/files\/2017\/10\/Wegner-e1579173572333-90x120.jpg 90w, https:\/\/www.izkf.med.fau.de\/files\/2017\/10\/Wegner-e1579173572333-180x240.jpg 180w, https:\/\/www.izkf.med.fau.de\/files\/2017\/10\/Wegner-e1579173572333-240x320.jpg 240w, https:\/\/www.izkf.med.fau.de\/files\/2017\/10\/Wegner-e1579173572333.jpg 266w\" \/><\/figure><\/td><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6311\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Fejtova-252x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Fejtova-252x300.jpg 252w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Fejtova-860x1024.jpg 860w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Fejtova-768x914.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Fejtova-1291x1536.jpg 1291w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Fejtova-50x60.jpg 50w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Fejtova-92x110.jpg 92w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Fejtova-202x240.jpg 202w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Fejtova-269x320.jpg 269w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Fejtova-395x470.jpg 395w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Fejtova.jpg 1388w\" \/><\/figure><\/td><\/tr><tr><td><strong>Principal Investigator<\/strong><br>Prof. Dr. Michael Wegner<br>E-Mail: michael.wegner@fau.de<\/td><td><strong>Principal Investigator<br><\/strong>Prof. Dr. Anna Fejtova<br>E-Mail: anna.fejtova@uk-erlangen.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"panel_3a1f06dc\" data-href=\"#panel_3a1f06dc\" type=\"button\" aria-expanded=\"false\" aria-controls=\"panel_3a1f06dc-section\" id=\"panel_3a1f06dc\">E38: Dieter Chichung Lie, Institute of Anatomy | Disease-relevant functions of SOX11 in mitosis<\/button><\/h2><div id=\"panel_3a1f06dc-section\" class=\"accordion-body \" aria-labelledby=\"panel_3a1f06dc\" role=\"region\" name=\"panel_3a1f06dc\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: Not started yet<\/p>\n\n\n<div class=\"alert clearfix clear alert-info \" title=\"\">\n\n<p>Heterozygous variants in the transcription factor SOX11 have been linked to a rare neurodevelopmental syndrome featuring intellectual disability and microcephaly. This project investigates the novel concept that SOX11 plays an essential role for mitotic spindle function through a non-transcriptional mechanism and that disruption of this mechanism contributes to the pathogenesis of SOX11-linked neurodevelopmental disorders.<\/p>\n\n<\/div>\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"panel_3a65b830\" data-href=\"#panel_3a65b830\" type=\"button\" aria-expanded=\"false\" aria-controls=\"panel_3a65b830-section\" id=\"panel_3a65b830\">E39: Christian M\u00fcller, Department of Psychiatry and Psychotherapy | Elisabeth Sock, Institute of Biochemistry | Alexey Ponomarenko, Institute of Physiology and Pathophysiology | Prefrontal Oligodendrocytes in Schizophrenia<\/button><\/h2><div id=\"panel_3a65b830-section\" class=\"accordion-body \" aria-labelledby=\"panel_3a65b830\" role=\"region\" name=\"panel_3a65b830\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: Not started yet<\/p>\n\n\n<div class=\"alert clearfix clear alert-info \" title=\"\">\n\n<p>This project investigates the role of oligodendroglia in schizophrenia, focusing on neural circuit dysfunction using a mouse model of psychosis. It assesses oligodendroglial function and prefrontal sphingolipid metabolism during psychosis induction and treatment, examines the impact of myelination on neural coding in cognitive circuits and studies the excitability of oligodendroglia in behaving mice. This research aims to advance understanding of schizophrenia pathogenesis and treatment.<\/p>\n\n<\/div>\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"panel_113ec394\" data-href=\"#panel_113ec394\" type=\"button\" aria-expanded=\"false\" aria-controls=\"panel_113ec394-section\" id=\"panel_113ec394\">E40: Jay Patankar, Department of Medicine 1 | Melanie K\u00fcspert, Institute of Biochemistry | Inflammation-Driven Glial Plasticity via Sox10<\/button><\/h2><div id=\"panel_113ec394-section\" class=\"accordion-body \" aria-labelledby=\"panel_113ec394\" role=\"region\" name=\"panel_113ec394\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: Not started yet<\/p>\n\n\n<div class=\"alert clearfix clear alert-info \" title=\"\">\n\n<p>Inflammatory bowel diseases impair gut neuro-immune circuits. While gut-innervating neurons are vulnerable to inflammation, satellite glia offer protection. Emerging evidence links glial plasticity to SOX10, but its regulation in gut-innervating ganglia remains unclear. We will investigate cytokine-driven modulation of SOX10 in glia of the myenteric, superior mesenteric, and dorsal root ganglia to uncover mechanisms of inflammation-induced plasticity and neuro-immune adaptation in colitis.<\/p>\n\n<\/div>\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"e41-peter-soba-institute-of-physiology-and-pathophysiology-axon-length-dependent-synapse-vulnerability\" data-href=\"#e41-peter-soba-institute-of-physiology-and-pathophysiology-axon-length-dependent-synapse-vulnerability\" type=\"button\" aria-expanded=\"false\" aria-controls=\"e41-peter-soba-institute-of-physiology-and-pathophysiology-axon-length-dependent-synapse-vulnerability-section\" id=\"e41-peter-soba-institute-of-physiology-and-pathophysiology-axon-length-dependent-synapse-vulnerability\">E41: Peter Soba, Institute of Physiology and Pathophysiology | Axon length-dependent synapse vulnerability<\/button><\/h2><div id=\"e41-peter-soba-institute-of-physiology-and-pathophysiology-axon-length-dependent-synapse-vulnerability-section\" class=\"accordion-body \" aria-labelledby=\"e41-peter-soba-institute-of-physiology-and-pathophysiology-axon-length-dependent-synapse-vulnerability\" role=\"region\" name=\"e41-peter-soba-institute-of-physiology-and-pathophysiology-axon-length-dependent-synapse-vulnerability\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.05.2026 &#8211; 31.10.2028<\/p>\n\n\n<div class=\"alert clearfix clear alert-info \" title=\"\">\n\n<p>Neurodegenerative disorders (NDs) frequently affect complex neurons with long axons. We hypothesize that axon length represents a molecularly defined source of intrinsic vulnerability to synapse loss, an early pathological feature of many NDs. We aim to identify these molecular signals, assay multiple ND-linked models and validate drivers of axon length-dependent synapse loss in human cells to provide insight into conserved molecular mechanisms as an entry point for early treatment of NDs.<\/p>\n\n<\/div>\n\n\n<figure class=\"wp-block-image size-thumbnail\"><div class=\"image-wrapper\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Soba-150x150.jpg\" alt=\"\" class=\"wp-image-6309 tall-image\" \/><button class=\"image-fullscreen-btn\" onclick=\"openImageFullscreen('https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Soba.jpg')\">\u26f6<\/button><\/div><figcaption class=\"wp-element-caption\">Principal Investigator<br>Prof. Dr. Peter Soba<br>peter.soba@fau.de<\/figcaption><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group med\"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"panel_abc011bd\" data-href=\"#panel_abc011bd\" type=\"button\" aria-expanded=\"false\" aria-controls=\"panel_abc011bd-section\" id=\"panel_abc011bd\">E42: Tomohisa Toda, Medical Institute of Biophysics | Martin Regensburger, Department of Molecular Neurology | Long-lived RNAs in Motor Neuron Diseases<\/button><\/h2><div id=\"panel_abc011bd-section\" class=\"accordion-body \" aria-labelledby=\"panel_abc011bd\" role=\"region\" name=\"panel_abc011bd\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: Not started yet<\/p>\n\n\n<div class=\"alert clearfix clear alert-info \" title=\"\">\n\n<p>The molecular basis of motor neuron vulnerability in motor neuron diseases (MNDs) remains poorly understood. RNA dysregulation has been linked to MNDs, and LL-RNAs have recently been identified as a potentially critical component of neural longevity. We found an enrichment of long-lived RNAs (LL-RNAs) in human motor neurons. Thus, this project will investigate the mechanistic role of LL-RNAs in MNDs using brain organoids, aiming to identify novel biomarkers and therapeutic targets.<\/p>\n\n<\/div>\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:35%\"><div class=\"faudir\">\r\n         <div class=\"format-compact\">\r\n        \r\n                <section class=\"format-compact-container\" aria-labelledby=\"section-title-63286880-4684\" itemscope itemtype=\"https:\/\/schema.org\/Person\">\r\n                                            <div class=\"profile-image-section\"> \r\n                            <figure class=\"signature\"><span class=\"text\">TT<\/span><\/figure>                        <\/div>\r\n                                            <header class=\"profile-header\">\r\n                       <h1 id=\"section-title-63286880-4684\"><a itemprop=\"url\" href=\"https:\/\/faudir.fau.de\/public\/person\/c6328688a0\"><span class=\"displayname\" itemprop=\"name\"><abbr title=\"Professor Doctor\" itemprop=\"honorificPrefix\">Prof. Dr.<\/abbr> <span class=\"namepart\"><span itemprop=\"givenName\">Tomohisa<\/span> <span itemprop=\"familyName\">Toda<\/span><\/span><\/span><\/a><\/h1><p class=\"organisation_name\"><span class=\"organization\" itemprop=\"name\">Professorship for Neural Epigenomics<\/span><\/p>                \r\n                     <\/header>\r\n                     <div class=\"profile-details\">   \r\n                        <div class=\"profile-contact\"><h2 class=\"contact-title\">Contact<\/h2><ul class=\"icon list-icons\"><li class=\"email listcontent\"><span class=\"value\"><span class=\"screen-reader-text\">Email: <\/span><a itemprop=\"email\" href=\"mailto:tomohisa.toda@fau.de\">tomohisa.toda@fau.de<\/a><\/span><\/li><\/ul><\/div>                 <\/div>\r\n                <\/section>    \r\n                <\/div>\r\n\r\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:35%\"><div class=\"faudir\">\r\n         <div class=\"format-compact\">\r\n        \r\n                <section class=\"format-compact-container\" aria-labelledby=\"section-title-890664-2593\" itemscope itemtype=\"https:\/\/schema.org\/Person\">\r\n                                            <div class=\"profile-image-section\"> \r\n                            <figure class=\"signature\"><span class=\"text\">MR<\/span><\/figure>                        <\/div>\r\n                                            <header class=\"profile-header\">\r\n                       <h1 id=\"section-title-890664-2593\"><a itemprop=\"url\" href=\"https:\/\/faudir.fau.de\/public\/person\/d89f06af64\"><span class=\"displayname\" itemprop=\"name\"><abbr title=\"Professor Doctor\" itemprop=\"honorificPrefix\">apl. Prof. Dr.<\/abbr> <span class=\"namepart\"><span itemprop=\"givenName\">Martin<\/span> <span itemprop=\"familyName\">Regensburger<\/span><\/span><\/span><\/a><\/h1>                \r\n                     <\/header>\r\n                     <div class=\"profile-details\">   \r\n                        <div class=\"profile-contact\"><h2 class=\"contact-title\">Contact<\/h2><ul class=\"icon list-icons\"><li class=\"email listcontent\"><span class=\"value\"><span class=\"screen-reader-text\">Email: <\/span><a itemprop=\"email\" href=\"mailto:martin.regensburger@fau.de\">martin.regensburger@fau.de<\/a><\/span><\/li><\/ul><\/div>                 <\/div>\r\n                <\/section>    \r\n                <\/div>\r\n\r\n<\/div><\/div>\n<\/div>\n\n<\/div><\/div><\/div><\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1355,"featured_media":0,"parent":6778,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"page-templates\/page-subnav.php","meta":{"_rrze_cache":"enabled","_access_permission":"","_rrze_multilang_single_locale":"en_GB","_rrze_multilang_single_source":"https:\/\/www.izkf.med.fau.de\/?page_id=578","footnotes":""},"page_category":[154],"page_tag":[],"workflow_usergroup":[],"class_list":["post-6811","page","type-page","status-publish","hentry","page_category-general","en-GB"],"_links":{"self":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/6811","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/users\/1355"}],"replies":[{"embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/comments?post=6811"}],"version-history":[{"count":9,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/6811\/revisions"}],"predecessor-version":[{"id":134559,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/6811\/revisions\/134559"}],"up":[{"embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/6778"}],"wp:attachment":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/media?parent=6811"}],"wp:term":[{"taxonomy":"page_category","embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/page_category?post=6811"},{"taxonomy":"page_tag","embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/page_tag?post=6811"},{"taxonomy":"workflow_usergroup","embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/workflow_usergroup?post=6811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}