{"id":6808,"date":"2023-04-24T17:17:25","date_gmt":"2023-04-24T15:17:25","guid":{"rendered":"https:\/\/www.izkf.med.fau.de\/?page_id=6808"},"modified":"2026-08-05T14:06:05","modified_gmt":"2026-08-05T12:06:05","slug":"tumorforschung","status":"publish","type":"page","link":"https:\/\/www.izkf.med.fau.de\/en\/projekte\/advancedprojects\/currentprojects\/tumorforschung\/","title":{"rendered":"Oncology"},"content":{"rendered":"<div class=\"wp-block-rrze-elements-collapsibles \"><div class=\"accordion\">\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"d44-claudia-guenther-department-of-medicine-1-elisabeth-naschberger-department-of-surgery-shaping-the-colorectal-niche\" data-href=\"#d44-claudia-guenther-department-of-medicine-1-elisabeth-naschberger-department-of-surgery-shaping-the-colorectal-niche\" type=\"button\" aria-expanded=\"false\" aria-controls=\"d44-claudia-guenther-department-of-medicine-1-elisabeth-naschberger-department-of-surgery-shaping-the-colorectal-niche-section\" id=\"d44-claudia-guenther-department-of-medicine-1-elisabeth-naschberger-department-of-surgery-shaping-the-colorectal-niche\" data-media-accordion-image-id=\"0\" data-media-accordion-image-url=\"\" data-media-accordion-image-alt=\"\" data-media-accordion-image-caption=\"\">D44: Claudia G\u00fcnther, Department of Medicine 1 | Elisabeth Naschberger, Department of Surgery | Shaping the Colorectal Niche<\/button><\/h2><div id=\"d44-claudia-guenther-department-of-medicine-1-elisabeth-naschberger-department-of-surgery-shaping-the-colorectal-niche-section\" class=\"accordion-body \" aria-labelledby=\"d44-claudia-guenther-department-of-medicine-1-elisabeth-naschberger-department-of-surgery-shaping-the-colorectal-niche\" role=\"region\" name=\"d44-claudia-guenther-department-of-medicine-1-elisabeth-naschberger-department-of-surgery-shaping-the-colorectal-niche\"><div class=\"accordion-inner clearfix\">\n\n<p class=\"wp-block-paragraph\">Term: 01.07.2026 &#8211; 31.12.2028<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The gut microbiota is a key contributor to colorectal cancer (CRC). Our data suggest that bacterial nanoparticles act as shuttles delivering microbial effectors to intestinal stem cells. We hypothesize that they promote CRC initiation and progression by transferring genotoxins and modulating the tumor microenvironment. This project aims to dissect how bacterial nanoparticles influence tumor cells and the TME.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"faudir\">\r\n             <ul class=\"format-list\">\r\n            <li class=\"text-list\" itemscope itemtype=\"https:\/\/schema.org\/Person\"><ul class=\"datalist list-icons\"><li class=\"faudir-displayname\"><span class=\"displayname\" itemprop=\"name\"><abbr title=\"Professor Doctor\" itemprop=\"honorificPrefix\">Prof. Dr.<\/abbr> <span class=\"namepart\"><span itemprop=\"givenName\">Claudia<\/span> <span itemprop=\"familyName\">G\u00fcnther<\/span><\/span><\/span><\/li><li class=\"faudir-email\"><span class=\"value icon\"><span class=\"screen-reader-text\">Email: <\/span><a itemprop=\"email\" href=\"mailto:claudia.guenther@fau.de\">claudia.guenther@fau.de<\/a><\/span><\/li><\/ul><\/li>            \r\n        <\/ul>\r\n    \r\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"faudir\">\r\n             <ul class=\"format-list\">\r\n            <li class=\"text-list\" itemscope itemtype=\"https:\/\/schema.org\/Person\"><ul class=\"datalist list-icons\"><li class=\"faudir-displayname\"><span class=\"displayname\" itemprop=\"name\"><abbr title=\"Professor Doctor\" itemprop=\"honorificPrefix\">Prof. Dr.<\/abbr> <span class=\"namepart\"><span itemprop=\"givenName\">Elisabeth<\/span> <span itemprop=\"familyName\">Naschberger<\/span><\/span><\/span><\/li><li class=\"faudir-email\"><span class=\"value icon\"><span class=\"screen-reader-text\">Email: <\/span><a itemprop=\"email\" href=\"mailto:elisabeth.naschberger@fau.de\">elisabeth.naschberger@fau.de<\/a><\/span><\/li><\/ul><\/li>            \r\n        <\/ul>\r\n    \r\n<\/div><\/div>\n<\/div>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"d45-reiner-strick-department-of-obstetrics-and-gynaecology-markus-eckstein-institute-of-pathology-regulation-of-s100a8-a9-in-bladder-cancer\" data-href=\"#d45-reiner-strick-department-of-obstetrics-and-gynaecology-markus-eckstein-institute-of-pathology-regulation-of-s100a8-a9-in-bladder-cancer\" type=\"button\" aria-expanded=\"false\" aria-controls=\"d45-reiner-strick-department-of-obstetrics-and-gynaecology-markus-eckstein-institute-of-pathology-regulation-of-s100a8-a9-in-bladder-cancer-section\" id=\"d45-reiner-strick-department-of-obstetrics-and-gynaecology-markus-eckstein-institute-of-pathology-regulation-of-s100a8-a9-in-bladder-cancer\" data-media-accordion-image-id=\"0\" data-media-accordion-image-url=\"\" data-media-accordion-image-alt=\"\" data-media-accordion-image-caption=\"\">D45: Reiner Strick, Department of Obstetrics and Gynaecology | Markus Eckstein, Institute of Pathology | Regulation of S100A8\/A9 in bladder cancer<\/button><\/h2><div id=\"d45-reiner-strick-department-of-obstetrics-and-gynaecology-markus-eckstein-institute-of-pathology-regulation-of-s100a8-a9-in-bladder-cancer-section\" class=\"accordion-body \" aria-labelledby=\"d45-reiner-strick-department-of-obstetrics-and-gynaecology-markus-eckstein-institute-of-pathology-regulation-of-s100a8-a9-in-bladder-cancer\" role=\"region\" name=\"d45-reiner-strick-department-of-obstetrics-and-gynaecology-markus-eckstein-institute-of-pathology-regulation-of-s100a8-a9-in-bladder-cancer\"><div class=\"accordion-inner clearfix\">\n\n<p class=\"wp-block-paragraph\">Term: 01.06.2026 &#8211; 30.11.2028<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We demonstrate inflammation of 218 urothelial bladder cancers is driven by the Endogenous Retrovirus interferon axis and identify five clusters. Cytokines S100A8\/A9 were the highest significantly differentially expressed genes. S100A8\/A9 also function in the nucleus and transcriptionally co-activate ERVs, but repress interferon stimulated genes. Analyses of bladder tumors for inflammation, S100A8\/A9 and ERVs will help to understand tumor progression and maintenance predicting clinical outcome.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"faudir\">\r\n             <ul class=\"format-list\">\r\n            <li class=\"text-list\" itemscope itemtype=\"https:\/\/schema.org\/Person\"><ul class=\"datalist list-icons\"><li class=\"faudir-displayname\"><span class=\"displayname\" itemprop=\"name\"><abbr title=\"Professor Doctor\" itemprop=\"honorificPrefix\">Prof. Dr.<\/abbr> <span class=\"namepart\"><span itemprop=\"givenName\">Reiner<\/span> <span itemprop=\"familyName\">Strick<\/span><\/span><\/span><\/li><li class=\"faudir-email\"><span class=\"value icon\"><span class=\"screen-reader-text\">Email: <\/span><a itemprop=\"email\" href=\"mailto:reiner.strick@fau.de\">reiner.strick@fau.de<\/a><\/span><\/li><\/ul><\/li>            \r\n        <\/ul>\r\n    \r\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"faudir\">\r\n             <ul class=\"format-list\">\r\n            <li class=\"text-list\" itemscope itemtype=\"https:\/\/schema.org\/Person\"><ul class=\"datalist list-icons\"><li class=\"faudir-displayname\"><span class=\"displayname\" itemprop=\"name\"><abbr title=\"Doctor Private lecturer\" itemprop=\"honorificPrefix\">PD Dr.<\/abbr> <span class=\"namepart\"><span itemprop=\"givenName\">Markus<\/span> <span itemprop=\"familyName\">Eckstein<\/span><\/span><\/span><\/li><li class=\"faudir-email\"><span class=\"value icon\"><span class=\"screen-reader-text\">Email: <\/span><a itemprop=\"email\" href=\"mailto:markus.eckstein@fau.de\">markus.eckstein@fau.de<\/a><\/span><\/li><\/ul><\/li>            \r\n        <\/ul>\r\n    \r\n<\/div><\/div>\n<\/div>\n\n<\/div><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1355,"featured_media":0,"parent":6778,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_rrze_cache":"enabled","_access_permission":"","_rrze_multilang_single_locale":"en_GB","_rrze_multilang_single_source":"https:\/\/www.izkf.med.fau.de\/?page_id=576","_faue_teaser_image_id":0,"footnotes":""},"page_category":[154],"page_tag":[],"workflow_usergroup":[],"class_list":["post-6808","page","type-page","status-publish","hentry","page_category-general","en-GB"],"faue_teaser_image_url":"","_links":{"self":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/6808","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/users\/1355"}],"replies":[{"embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/comments?post=6808"}],"version-history":[{"count":10,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/6808\/revisions"}],"predecessor-version":[{"id":144323,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/6808\/revisions\/144323"}],"up":[{"embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/6778"}],"wp:attachment":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/media?parent=6808"}],"wp:term":[{"taxonomy":"page_category","embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/page_category?post=6808"},{"taxonomy":"page_tag","embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/page_tag?post=6808"},{"taxonomy":"workflow_usergroup","embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/workflow_usergroup?post=6808"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}