{"id":6805,"date":"2023-04-24T17:16:01","date_gmt":"2023-04-24T15:16:01","guid":{"rendered":"https:\/\/www.izkf.med.fau.de\/?page_id=6805"},"modified":"2026-03-24T13:38:19","modified_gmt":"2026-03-24T12:38:19","slug":"infektionsforschung-und-immunologie","status":"publish","type":"page","link":"https:\/\/www.izkf.med.fau.de\/en\/projekte\/advancedprojects\/currentprojects\/infektionsforschung-und-immunologie\/","title":{"rendered":"Immunology and Infection"},"content":{"rendered":"<div class=\"wp-block-rrze-elements-collapsibles \"><div class=\"accordion\">\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"a93-christoph-becker-department-of-medicine-1-cytosolic-citrate-metabolism-in-iec\" data-href=\"#a93-christoph-becker-department-of-medicine-1-cytosolic-citrate-metabolism-in-iec\" type=\"button\" aria-expanded=\"false\" aria-controls=\"a93-christoph-becker-department-of-medicine-1-cytosolic-citrate-metabolism-in-iec-section\" id=\"a93-christoph-becker-department-of-medicine-1-cytosolic-citrate-metabolism-in-iec\">A93: Christoph Becker, Department of Medicine 1 | Cytosolic citrate metabolism in IEC<\/button><\/h2><div id=\"a93-christoph-becker-department-of-medicine-1-cytosolic-citrate-metabolism-in-iec-section\" class=\"accordion-body \" aria-labelledby=\"a93-christoph-becker-department-of-medicine-1-cytosolic-citrate-metabolism-in-iec\" role=\"region\" name=\"a93-christoph-becker-department-of-medicine-1-cytosolic-citrate-metabolism-in-iec\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.07.2023 &#8211;&nbsp;30.06.2026<\/p>\n\n\n\n<p>We have identified the enzyme ATP Citrate Lyase (ACLY) as a key immunometabolic regulator of intestinal inflammation. We therefore hypothesize that diminished ACLY expression in the intestinal epithelium drives the pathogenesis of Inflammatory Bowel Disease. To evaluate our hypothesis, we plan to elucidate the regulation of Acly, its molecular mode of action and its functional impact for the steady-state gut and for intestinal inflammation using newly generated knockout mice.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-4396\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2021\/03\/becker-christoph-248x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2021\/03\/becker-christoph-248x300.jpg 248w, https:\/\/www.izkf.med.fau.de\/files\/2021\/03\/becker-christoph-848x1024.jpg 848w, https:\/\/www.izkf.med.fau.de\/files\/2021\/03\/becker-christoph-768x928.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2021\/03\/becker-christoph-1272x1536.jpg 1272w, https:\/\/www.izkf.med.fau.de\/files\/2021\/03\/becker-christoph-199x240.jpg 199w, https:\/\/www.izkf.med.fau.de\/files\/2021\/03\/becker-christoph-265x320.jpg 265w, https:\/\/www.izkf.med.fau.de\/files\/2021\/03\/becker-christoph-389x470.jpg 389w, https:\/\/www.izkf.med.fau.de\/files\/2021\/03\/becker-christoph.jpg 1656w\" \/><\/figure><\/td><\/tr><tr><td><strong>Principal Investigator<\/strong><br>Prof. Dr. Christoph Becker<br>E-Mail: christoph.becker@uk-erlangen.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"a94-armin-ensser-institute-of-clinical-and-molecular-virology-sars-cov-2-host-adaptation\" data-href=\"#a94-armin-ensser-institute-of-clinical-and-molecular-virology-sars-cov-2-host-adaptation\" type=\"button\" aria-expanded=\"false\" aria-controls=\"a94-armin-ensser-institute-of-clinical-and-molecular-virology-sars-cov-2-host-adaptation-section\" id=\"a94-armin-ensser-institute-of-clinical-and-molecular-virology-sars-cov-2-host-adaptation\">A94: Armin Ensser, Institute of Clinical and Molecular Virology | SARS-CoV-2 host adaptation<\/button><\/h2><div id=\"a94-armin-ensser-institute-of-clinical-and-molecular-virology-sars-cov-2-host-adaptation-section\" class=\"accordion-body \" aria-labelledby=\"a94-armin-ensser-institute-of-clinical-and-molecular-virology-sars-cov-2-host-adaptation\" role=\"region\" name=\"a94-armin-ensser-institute-of-clinical-and-molecular-virology-sars-cov-2-host-adaptation\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.07.2023 &#8211; 30.06.2026<\/p>\n\n\n\n<p>The continuous adaptation of the SARS-CoV-2 replicative machinery, as well as the consequences of nonstructural protein (Nsp) mutations to the virus-host interaction need to be considered in emerging variants. SARS-CoV-2 marker viruses will be used to address the role of existing and new variant virus mutations in Nsp\u2019s in different culture systems, in viral replication and in their escape from cellular restriction, focusing on the non-spike related phenotype of these variants.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6285\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Ensser_bearbeitet-250x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Ensser_bearbeitet-250x300.jpg 250w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Ensser_bearbeitet-853x1024.jpg 853w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Ensser_bearbeitet-768x922.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Ensser_bearbeitet-1280x1536.jpg 1280w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Ensser_bearbeitet-1707x2048.jpg 1707w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Ensser_bearbeitet-50x60.jpg 50w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Ensser_bearbeitet-92x110.jpg 92w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Ensser_bearbeitet-200x240.jpg 200w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Ensser_bearbeitet-267x320.jpg 267w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Ensser_bearbeitet-392x470.jpg 392w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Ensser_bearbeitet.jpg 1889w\" \/><\/figure><\/td><\/tr><tr><td><strong>Principal Investigator<\/strong><br>Prof. Dr. Armin Ensser<br>E-Mail: armin.ensser@fau.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"a95-thomas-gramberg-institute-of-clinical-and-molecular-virology-viral-rna-methylation-inhibits-mda5-sensing\" data-href=\"#a95-thomas-gramberg-institute-of-clinical-and-molecular-virology-viral-rna-methylation-inhibits-mda5-sensing\" type=\"button\" aria-expanded=\"false\" aria-controls=\"a95-thomas-gramberg-institute-of-clinical-and-molecular-virology-viral-rna-methylation-inhibits-mda5-sensing-section\" id=\"a95-thomas-gramberg-institute-of-clinical-and-molecular-virology-viral-rna-methylation-inhibits-mda5-sensing\">A95: Thomas Gramberg, Institute of Clinical and Molecular Virology | Viral RNA methylation inhibits MDA5 sensing<\/button><\/h2><div id=\"a95-thomas-gramberg-institute-of-clinical-and-molecular-virology-viral-rna-methylation-inhibits-mda5-sensing-section\" class=\"accordion-body \" aria-labelledby=\"a95-thomas-gramberg-institute-of-clinical-and-molecular-virology-viral-rna-methylation-inhibits-mda5-sensing\" role=\"region\" name=\"a95-thomas-gramberg-institute-of-clinical-and-molecular-virology-viral-rna-methylation-inhibits-mda5-sensing\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.01.2023 &#8211; 31.12.2025 <\/p>\n\n\n\n<p>2\u2019-O-Methylation of mRNA by cellular methyltransferases (MTases) enables discrimination of self and non-self. We found that SARS-CoV-2 lacking the viral MTase Nsp16 triggers an enhanced innate immune response that depends on the RNA receptor MDA5. Thus, we will analyse Nsp16 as a means of SARS-CoV-2 to counteract innate immune sensing and will test the hypothesis that the 2\u2019-O-methylation of viral RNA in general protects from sensing by the pattern recognition receptor MDA5.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6286\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/gramberg-250x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/gramberg-250x300.jpg 250w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/gramberg-853x1024.jpg 853w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/gramberg-768x922.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/gramberg-1280x1536.jpg 1280w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/gramberg-50x60.jpg 50w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/gramberg-92x110.jpg 92w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/gramberg-200x240.jpg 200w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/gramberg-267x320.jpg 267w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/gramberg-392x470.jpg 392w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/gramberg.jpg 1649w\" \/><\/figure><\/td><\/tr><tr><td><strong>Principal Investigator<\/strong><br>Prof. Dr. Thomas Gramberg<br>E-Mail: thomas.gramberg@fau.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"a96-kai-hildner-department-of-medicine-1-thomas-winkler-department-biology-chair-of-genetics-immune-iec-crosstalk-during-intestinal-cmv\" data-href=\"#a96-kai-hildner-department-of-medicine-1-thomas-winkler-department-biology-chair-of-genetics-immune-iec-crosstalk-during-intestinal-cmv\" type=\"button\" aria-expanded=\"false\" aria-controls=\"a96-kai-hildner-department-of-medicine-1-thomas-winkler-department-biology-chair-of-genetics-immune-iec-crosstalk-during-intestinal-cmv-section\" id=\"a96-kai-hildner-department-of-medicine-1-thomas-winkler-department-biology-chair-of-genetics-immune-iec-crosstalk-during-intestinal-cmv\">A96: Kai Hildner, Department of Medicine 1 | Thomas Winkler, Department Biology &#8211; Chair of Genetics | Immune\/ IEC crosstalk during intestinal CMV<\/button><\/h2><div id=\"a96-kai-hildner-department-of-medicine-1-thomas-winkler-department-biology-chair-of-genetics-immune-iec-crosstalk-during-intestinal-cmv-section\" class=\"accordion-body \" aria-labelledby=\"a96-kai-hildner-department-of-medicine-1-thomas-winkler-department-biology-chair-of-genetics-immune-iec-crosstalk-during-intestinal-cmv\" role=\"region\" name=\"a96-kai-hildner-department-of-medicine-1-thomas-winkler-department-biology-chair-of-genetics-immune-iec-crosstalk-during-intestinal-cmv\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.05.2023 &#8211; 30.04.2026 <\/p>\n\n\n\n<p>Reactivation of latent Cytomegalovirus (CMV) infections represent a severe, life-threatening intestinal complication in immunocompromised patients. Underlying cellular and molecular mechanisms regulating the immune epithelial cell interaction are only partially understood and targeted treatment options are not available. We seek to decipher the immune \/ epithelial cell interaction in the context of CMV infection combining novel ex vivo organoid co-culture with innovative genetic model systems<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6287\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/hildner-250x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/hildner-250x300.jpg 250w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/hildner-854x1024.jpg 854w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/hildner-768x921.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/hildner-1280x1536.jpg 1280w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/hildner-50x60.jpg 50w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/hildner-92x110.jpg 92w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/hildner-200x240.jpg 200w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/hildner-267x320.jpg 267w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/hildner-392x470.jpg 392w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/hildner.jpg 1508w\" \/><\/figure><\/td><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6288\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/winklert-250x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/winklert-250x300.jpg 250w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/winklert-853x1024.jpg 853w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/winklert-768x922.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/winklert-1280x1536.jpg 1280w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/winklert-1706x2048.jpg 1706w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/winklert-50x60.jpg 50w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/winklert-92x110.jpg 92w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/winklert-200x240.jpg 200w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/winklert-267x320.jpg 267w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/winklert-392x470.jpg 392w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/winklert.jpg 1753w\" \/><\/figure><\/td><\/tr><tr><td><strong>Principal Investigator<\/strong><br>Prof. Dr. Kai Hildner<br>E-Mail: kai.hildner@uk-erlangen.de<\/td><td><strong>Principal Investigator<br><\/strong>Prof. Dr. Thomas Winkler<br>E-Mail: thomas.winkler@fau.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"a97-clemens-neufert-department-of-medicine-1-stat3-in-imcs-during-mucosal-healing-in-ibd\" data-href=\"#a97-clemens-neufert-department-of-medicine-1-stat3-in-imcs-during-mucosal-healing-in-ibd\" type=\"button\" aria-expanded=\"false\" aria-controls=\"a97-clemens-neufert-department-of-medicine-1-stat3-in-imcs-during-mucosal-healing-in-ibd-section\" id=\"a97-clemens-neufert-department-of-medicine-1-stat3-in-imcs-during-mucosal-healing-in-ibd\">A97: Clemens Neufert, Department of Medicine 1 | STAT3 in IMCs during mucosal healing in IBD<\/button><\/h2><div id=\"a97-clemens-neufert-department-of-medicine-1-stat3-in-imcs-during-mucosal-healing-in-ibd-section\" class=\"accordion-body \" aria-labelledby=\"a97-clemens-neufert-department-of-medicine-1-stat3-in-imcs-during-mucosal-healing-in-ibd\" role=\"region\" name=\"a97-clemens-neufert-department-of-medicine-1-stat3-in-imcs-during-mucosal-healing-in-ibd\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.07.2023 &#8211; 30.06.2026 <\/p>\n\n\n\n<p>The function of intestinal mesenchymal cells (IMCs) in inflammatory bowel diseases (IBD) has not been clarified yet. The goal of this project is to characterize and to functionally study the role of STAT3 activation in IMCs during mucosal healing in the gut by using established in vivo models and human tissue specimens. Perspectively, these studies aim to pave the way for novel therapeutic options in IBD care.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6289\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/neufert-250x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/neufert-250x300.jpg 250w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/neufert-853x1024.jpg 853w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/neufert-768x922.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/neufert-1280x1536.jpg 1280w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/neufert-50x60.jpg 50w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/neufert-92x110.jpg 92w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/neufert-200x240.jpg 200w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/neufert-267x320.jpg 267w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/neufert-392x470.jpg 392w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/neufert.jpg 1690w\" \/><\/figure><\/td><\/tr><tr><td><strong>Principal Investigator<\/strong><br>Prof. Dr. Clemens Neufert<br>E-Mail: clemens.neufert@uk-erlangen.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"a99-ulrike-steffen-department-of-medicine-3-mechanisms-of-cortical-bone-remodelling\" data-href=\"#a99-ulrike-steffen-department-of-medicine-3-mechanisms-of-cortical-bone-remodelling\" type=\"button\" aria-expanded=\"false\" aria-controls=\"a99-ulrike-steffen-department-of-medicine-3-mechanisms-of-cortical-bone-remodelling-section\" id=\"a99-ulrike-steffen-department-of-medicine-3-mechanisms-of-cortical-bone-remodelling\">A99: Ulrike Steffen, Department of Medicine 3 | Mechanisms of cortical bone remodelling<\/button><\/h2><div id=\"a99-ulrike-steffen-department-of-medicine-3-mechanisms-of-cortical-bone-remodelling-section\" class=\"accordion-body \" aria-labelledby=\"a99-ulrike-steffen-department-of-medicine-3-mechanisms-of-cortical-bone-remodelling\" role=\"region\" name=\"a99-ulrike-steffen-department-of-medicine-3-mechanisms-of-cortical-bone-remodelling\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.07.2023 &#8211; 30.06.2026<\/p>\n\n\n\n<p>Constant bone remodelling is important to prevent fractures. In bones with a thick cortex, we found that remodelling is based on endosteal bone formation and periosteal resorption which stands in contrast to existing models. In this project we will characterize this process and analyse its dependence on age, mechanical load, osteoclast and osteocyte activity. We aim to explain why some bone sites are prone to fracture and to develop new treatment strategies to prevent insufficiency fracture.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6291\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Steffen-250x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Steffen-250x300.jpg 250w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Steffen-854x1024.jpg 854w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Steffen-768x921.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Steffen-1281x1536.jpg 1281w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Steffen-50x60.jpg 50w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Steffen-92x110.jpg 92w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Steffen-200x240.jpg 200w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Steffen-267x320.jpg 267w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Steffen-392x470.jpg 392w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Steffen.jpg 1630w\" \/><\/figure><\/td><\/tr><tr><td><strong>Principal Investigator<\/strong><br>Dr. Ulrike Steffen<br>E-Mail: ulrike.steffen@uk-erlangen.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"a100-alexander-steinkasserer-department-of-immune-modulations-cd83-induces-wound-healing\" data-href=\"#a100-alexander-steinkasserer-department-of-immune-modulations-cd83-induces-wound-healing\" type=\"button\" aria-expanded=\"false\" aria-controls=\"a100-alexander-steinkasserer-department-of-immune-modulations-cd83-induces-wound-healing-section\" id=\"a100-alexander-steinkasserer-department-of-immune-modulations-cd83-induces-wound-healing\">A100: Alexander Steinkasserer, Department of Immune Modulations | CD83 induces wound healing<\/button><\/h2><div id=\"a100-alexander-steinkasserer-department-of-immune-modulations-cd83-induces-wound-healing-section\" class=\"accordion-body \" aria-labelledby=\"a100-alexander-steinkasserer-department-of-immune-modulations-cd83-induces-wound-healing\" role=\"region\" name=\"a100-alexander-steinkasserer-department-of-immune-modulations-cd83-induces-wound-healing\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.07.2023 &#8211; 31.12.2026 <\/p>\n\n\n\n<p>New medications for the treatment of chronic wounds are urgently needed. Our preliminary data show that sCD83 accelerated wound healing processes in a systemic as well as a topical treatment. Cellular analyses revealed the increase of pro-resolving macrophages, known to improve wound healing processes. These striking regenerative capacities make scD83 a promising candidate to treat chronic- and hard-to-heal wounds. Within the current project we aim to elucidate the underlying mechanisms.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-3579\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2020\/01\/Steinkasserer-e1675254032689-262x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2020\/01\/Steinkasserer-e1675254032689-262x300.jpg 262w, https:\/\/www.izkf.med.fau.de\/files\/2020\/01\/Steinkasserer-e1675254032689-894x1024.jpg 894w, https:\/\/www.izkf.med.fau.de\/files\/2020\/01\/Steinkasserer-e1675254032689-768x880.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2020\/01\/Steinkasserer-e1675254032689-210x240.jpg 210w, https:\/\/www.izkf.med.fau.de\/files\/2020\/01\/Steinkasserer-e1675254032689-279x320.jpg 279w, https:\/\/www.izkf.med.fau.de\/files\/2020\/01\/Steinkasserer-e1675254032689-410x470.jpg 410w, https:\/\/www.izkf.med.fau.de\/files\/2020\/01\/Steinkasserer-e1675254032689-52x60.jpg 52w, https:\/\/www.izkf.med.fau.de\/files\/2020\/01\/Steinkasserer-e1675254032689-96x110.jpg 96w, https:\/\/www.izkf.med.fau.de\/files\/2020\/01\/Steinkasserer-e1675254032689.jpg 1102w\" \/><\/figure><\/td><\/tr><tr><td><strong>Principal Investigator<\/strong><br>Prof. Dr. Alexander Steinkasserer<br>E-Mail: alexander.steinkasserer@uk-erlangen.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"a101-matthias-tenbusch-institute-of-clinical-and-molecular-virology-igg4-responses-after-sars-cov-2-rna-vaccination\" data-href=\"#a101-matthias-tenbusch-institute-of-clinical-and-molecular-virology-igg4-responses-after-sars-cov-2-rna-vaccination\" type=\"button\" aria-expanded=\"false\" aria-controls=\"a101-matthias-tenbusch-institute-of-clinical-and-molecular-virology-igg4-responses-after-sars-cov-2-rna-vaccination-section\" id=\"a101-matthias-tenbusch-institute-of-clinical-and-molecular-virology-igg4-responses-after-sars-cov-2-rna-vaccination\">A101: Matthias Tenbusch, Institute of Clinical and Molecular Virology | IgG4 responses after SARS-CoV-2 RNA vaccination<\/button><\/h2><div id=\"a101-matthias-tenbusch-institute-of-clinical-and-molecular-virology-igg4-responses-after-sars-cov-2-rna-vaccination-section\" class=\"accordion-body \" aria-labelledby=\"a101-matthias-tenbusch-institute-of-clinical-and-molecular-virology-igg4-responses-after-sars-cov-2-rna-vaccination\" role=\"region\" name=\"a101-matthias-tenbusch-institute-of-clinical-and-molecular-virology-igg4-responses-after-sars-cov-2-rna-vaccination\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.04.2023 &#8211; 31.03.2026<\/p>\n\n\n\n<p>Recently, we identified atypical, antiviral IgG4 responses after immunizations with a SARS-CoV-2 mRNA vaccine. Since IgG4 responses are considered as anti-infammatory and rather tolerogenic, the impact of this type of antibody response on preventing viral infections or disease will be elucidated. Whether antigen re-exposures in form of infections or boost immunization will further shift the SARS-CoV-2 response towards IgG4 will be analysed as well as potential underlying mechanisms.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-3522\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2020\/01\/gp_tenbusch-matthias_7551klein-e1579005705753-231x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2020\/01\/gp_tenbusch-matthias_7551klein-e1579005705753-231x300.jpg 231w, https:\/\/www.izkf.med.fau.de\/files\/2020\/01\/gp_tenbusch-matthias_7551klein-e1579005705753-184x240.jpg 184w, https:\/\/www.izkf.med.fau.de\/files\/2020\/01\/gp_tenbusch-matthias_7551klein-e1579005705753-246x320.jpg 246w, https:\/\/www.izkf.med.fau.de\/files\/2020\/01\/gp_tenbusch-matthias_7551klein-e1579005705753-361x470.jpg 361w, https:\/\/www.izkf.med.fau.de\/files\/2020\/01\/gp_tenbusch-matthias_7551klein-e1579005705753.jpg 395w\" \/><\/figure><\/td><\/tr><tr><td><strong>Principal Investigator<\/strong><br>Prof. Dr. Matthias Tenbusch<br>E-Mail: matthias.tenbusch@uk-erlangen.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"a102-maximilian-waldner-department-of-medicine-1-jochen-guck-dep-of-physics-chair-of-biological-optomechanics-mechanics-of-innate-immune-cells-in-colitis\" data-href=\"#a102-maximilian-waldner-department-of-medicine-1-jochen-guck-dep-of-physics-chair-of-biological-optomechanics-mechanics-of-innate-immune-cells-in-colitis\" type=\"button\" aria-expanded=\"false\" aria-controls=\"a102-maximilian-waldner-department-of-medicine-1-jochen-guck-dep-of-physics-chair-of-biological-optomechanics-mechanics-of-innate-immune-cells-in-colitis-section\" id=\"a102-maximilian-waldner-department-of-medicine-1-jochen-guck-dep-of-physics-chair-of-biological-optomechanics-mechanics-of-innate-immune-cells-in-colitis\">A102: Maximilian Waldner, Department of Medicine 1 | Jochen Guck \u2020, Dep. of Physics &#8211; Chair of Biological Optomechanics | Mechanics of innate immune cells in colitis<\/button><\/h2><div id=\"a102-maximilian-waldner-department-of-medicine-1-jochen-guck-dep-of-physics-chair-of-biological-optomechanics-mechanics-of-innate-immune-cells-in-colitis-section\" class=\"accordion-body \" aria-labelledby=\"a102-maximilian-waldner-department-of-medicine-1-jochen-guck-dep-of-physics-chair-of-biological-optomechanics-mechanics-of-innate-immune-cells-in-colitis\" role=\"region\" name=\"a102-maximilian-waldner-department-of-medicine-1-jochen-guck-dep-of-physics-chair-of-biological-optomechanics-mechanics-of-innate-immune-cells-in-colitis\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.07.2023 &#8211; 30.06.2026<\/p>\n\n\n\n<p>Immune cell trafficking plays a central role in the pathogenesis of ulcerative colitis (UC). Based on our preliminary data, we propose cell mechanics as an important mechanism in this process. To explore this hypothesis, we will investigate mechanisms regulating mechanics of innate immune cells in colitis models. We will further explore the functional consequences of immune cell deformability in acute colitis and explore therapeutic opportunities for a modulation of cell mechanics in UC.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1189\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2017\/10\/Waldner-250x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2017\/10\/Waldner-250x300.jpg 250w, https:\/\/www.izkf.med.fau.de\/files\/2017\/10\/Waldner-125x150.jpg 125w, https:\/\/www.izkf.med.fau.de\/files\/2017\/10\/Waldner.jpg 295w, https:\/\/www.izkf.med.fau.de\/files\/2017\/10\/Waldner-123x147.jpg 123w, https:\/\/www.izkf.med.fau.de\/files\/2017\/10\/Waldner-92x110.jpg 92w, https:\/\/www.izkf.med.fau.de\/files\/2017\/10\/Waldner-167x200.jpg 167w, https:\/\/www.izkf.med.fau.de\/files\/2017\/10\/Waldner-100x120.jpg 100w\" \/><\/figure><\/td><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6292\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Guck-scaled-e1675254335660-228x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Guck-scaled-e1675254335660-228x300.jpg 228w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Guck-scaled-e1675254335660-779x1024.jpg 779w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Guck-scaled-e1675254335660-768x1010.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Guck-scaled-e1675254335660-1168x1536.jpg 1168w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Guck-scaled-e1675254335660-1557x2048.jpg 1557w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Guck-scaled-e1675254335660-46x60.jpg 46w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Guck-scaled-e1675254335660-84x110.jpg 84w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Guck-scaled-e1675254335660-183x240.jpg 183w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Guck-scaled-e1675254335660-243x320.jpg 243w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Guck-scaled-e1675254335660-357x470.jpg 357w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Guck-scaled-e1675254335660.jpg 1708w\" \/><\/figure><\/td><\/tr><tr><td><strong>Principal Investigator<\/strong><br>Prof. Dr. Maximilian Waldner<br>E-Mail: maximilian.waldner@uk-erlangen.de<\/td><td><strong>Principal Investigator<br><\/strong>Prof. Dr. Jochen Guck \u2020<br>E-Mail: jochen.guck@mpl.mpg.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"a103-benno-weigmann-department-of-medicine-1-secretory-iga-molecules-in-intestinal-immunity\" data-href=\"#a103-benno-weigmann-department-of-medicine-1-secretory-iga-molecules-in-intestinal-immunity\" type=\"button\" aria-expanded=\"false\" aria-controls=\"a103-benno-weigmann-department-of-medicine-1-secretory-iga-molecules-in-intestinal-immunity-section\" id=\"a103-benno-weigmann-department-of-medicine-1-secretory-iga-molecules-in-intestinal-immunity\">A103: Benno Weigmann, Department of Medicine 1 | Secretory IgA molecules in intestinal immunity<\/button><\/h2><div id=\"a103-benno-weigmann-department-of-medicine-1-secretory-iga-molecules-in-intestinal-immunity-section\" class=\"accordion-body \" aria-labelledby=\"a103-benno-weigmann-department-of-medicine-1-secretory-iga-molecules-in-intestinal-immunity\" role=\"region\" name=\"a103-benno-weigmann-department-of-medicine-1-secretory-iga-molecules-in-intestinal-immunity\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.07.2023 &#8211; 30.06.2026<\/p>\n\n\n\n<p>Intestinal diseases (IBD) are chronic inflammations of the gastrointestinal tract. Secretory antibodies (SIgA) are produced by mucosal surfaces and are intestinal defences. The project aims to elucidate the role of SIgA in the uptake\/retro process at the endothelium. Furthermore, an analysis of the SIgA-selected bacterial strains in the intestine will be carried out and new targets for a SIgA-mediated therapeutic approach in therapy will be found.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6293\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Weigmann-274x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Weigmann-274x300.jpg 274w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Weigmann-55x60.jpg 55w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Weigmann-100x110.jpg 100w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Weigmann-219x240.jpg 219w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Weigmann-292x320.jpg 292w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Weigmann-429x470.jpg 429w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/Weigmann.jpg 677w\" \/><\/figure><\/td><\/tr><tr><td><strong>Principal Investigator<\/strong><br>PD Dr. Benno Weigmann<br>E-Mail: benno.weigmann@uk-erlangen.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"a104-sebastian-zundler-department-of-medicine-1-stefan-uderhardt-department-of-medicine-3-mechanical-regulation-of-intestinal-t-cell-egress\" data-href=\"#a104-sebastian-zundler-department-of-medicine-1-stefan-uderhardt-department-of-medicine-3-mechanical-regulation-of-intestinal-t-cell-egress\" type=\"button\" aria-expanded=\"false\" aria-controls=\"a104-sebastian-zundler-department-of-medicine-1-stefan-uderhardt-department-of-medicine-3-mechanical-regulation-of-intestinal-t-cell-egress-section\" id=\"a104-sebastian-zundler-department-of-medicine-1-stefan-uderhardt-department-of-medicine-3-mechanical-regulation-of-intestinal-t-cell-egress\">A104: Sebastian Zundler, Department of Medicine 1 | Stefan Uderhardt, Department of Medicine 3 | Mechanical regulation of intestinal T cell egress<\/button><\/h2><div id=\"a104-sebastian-zundler-department-of-medicine-1-stefan-uderhardt-department-of-medicine-3-mechanical-regulation-of-intestinal-t-cell-egress-section\" class=\"accordion-body \" aria-labelledby=\"a104-sebastian-zundler-department-of-medicine-1-stefan-uderhardt-department-of-medicine-3-mechanical-regulation-of-intestinal-t-cell-egress\" role=\"region\" name=\"a104-sebastian-zundler-department-of-medicine-1-stefan-uderhardt-department-of-medicine-3-mechanical-regulation-of-intestinal-t-cell-egress\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 16.01.2023 &#8211; 31.05.2026 <\/p>\n\n\n\n<p>It is still unclear, how the in vivo trafficking of autoreactive T cells in IBD is coordinated. Preliminary data indicate that mechanical properties regulate the motility of gut T cells. Thus, we aim to investigate the interplay of intestinal T cell mechanics and trafficking in a joint effort combining the expertise of two clinician scientist PIs in cell trafficking and bioimaging. We ultimately hope to identify new targets for organ-selective IBD therapy controlling T cell dynamics in the gut.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2161\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2018\/01\/Zundler-e1579167057915-225x300.jpg\" alt=\"Foto Zundler\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2018\/01\/Zundler-e1579167057915-225x300.jpg 225w, https:\/\/www.izkf.med.fau.de\/files\/2018\/01\/Zundler-e1579167057915-60x80.jpg 60w, https:\/\/www.izkf.med.fau.de\/files\/2018\/01\/Zundler-e1579167057915-90x120.jpg 90w, https:\/\/www.izkf.med.fau.de\/files\/2018\/01\/Zundler-e1579167057915-180x240.jpg 180w, https:\/\/www.izkf.med.fau.de\/files\/2018\/01\/Zundler-e1579167057915.jpg 265w, https:\/\/www.izkf.med.fau.de\/files\/2018\/01\/Zundler-e1579167057915-240x320.jpg 240w\" \/><\/figure><\/td><td><figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6294\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/uderhardt-250x300.jpg\" alt=\"\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/uderhardt-250x300.jpg 250w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/uderhardt-853x1024.jpg 853w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/uderhardt-768x922.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/uderhardt-1280x1536.jpg 1280w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/uderhardt-1707x2048.jpg 1707w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/uderhardt-50x60.jpg 50w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/uderhardt-92x110.jpg 92w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/uderhardt-200x240.jpg 200w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/uderhardt-267x320.jpg 267w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/uderhardt-392x470.jpg 392w, https:\/\/www.izkf.med.fau.de\/files\/2023\/02\/uderhardt.jpg 1735w\" \/><\/figure><\/td><\/tr><tr><td><strong>Principal Investigator<\/strong><br>Prof. Dr. Dr. Sebastian Zundler<br>E-Mail: sebastian.zundler@uk-erlangen.de<\/td><td><strong>Principal Investigator<br><\/strong>Prof. Dr. Stefan Uderhardt<br>E-Mail: stefan.uderhardt@uk-erlangen.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"panel_1f8d8662\" data-href=\"#panel_1f8d8662\" type=\"button\" aria-expanded=\"false\" aria-controls=\"panel_1f8d8662-section\" id=\"panel_1f8d8662\">A105: Imke Atreya, Department of Medicine 1 | VRAC as a regulator of T cell-driven colitis<\/button><\/h2><div id=\"panel_1f8d8662-section\" class=\"accordion-body \" aria-labelledby=\"panel_1f8d8662\" role=\"region\" name=\"panel_1f8d8662\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: not started yet<\/p>\n\n\n<div class=\"alert clearfix clear alert-default \" title=\"\">\n\n<p>We will define the relevance of VRAC for T cell function in colitis and validate VRAC as a potential target for IBD therapy. Our initial data point to a functional role of VRAC in T cell-driven colitis and implicate that VRAC modulates immunometabolism and mechanical properties of T cells. Using VRAC KO mice and IBD tissue samples, we will elucidate the colitis-regulating capacity of VRAC in T cells, identify modulators of VRAC expression and define its interplay with T cell immunometabolism.<\/p>\n\n\n\n\n\n<\/div>\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"panel_6d56ff7e\" data-href=\"#panel_6d56ff7e\" type=\"button\" aria-expanded=\"false\" aria-controls=\"panel_6d56ff7e-section\" id=\"panel_6d56ff7e\">A106: Christoph Becker, Department of Medicine 1 | Luis Munoz, Department of Medicine 3 | Role of RIP kinases in Sj\u00f6gren Syndrom<\/button><\/h2><div id=\"panel_6d56ff7e-section\" class=\"accordion-body \" aria-labelledby=\"panel_6d56ff7e\" role=\"region\" name=\"panel_6d56ff7e\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: not started yet<\/p>\n\n\n\n<p>Primary Sj\u00f6gren\u2019s syndrome (PSS) is an autoimmune disease causing chronic inflammation of exocrine glands, dry mouth and eyes. Our preliminary data identify RIP kinases as&nbsp; novel regulators of salivary gland homeostasis and potential factors in PSS. Inducible RIP kinase-deficient mice develop PSS-like disease and implicate this kinase in immune regulation and epithelial homeostasis within the salivary gland. This proposal aims to clarify the role of RIP kinases in the salivary gland and in PSS.<\/p>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"a108-jochen-mattner-institute-of-microbiology-amino-acids-colonization-resistance-salmonella\" data-href=\"#a108-jochen-mattner-institute-of-microbiology-amino-acids-colonization-resistance-salmonella\" type=\"button\" aria-expanded=\"false\" aria-controls=\"a108-jochen-mattner-institute-of-microbiology-amino-acids-colonization-resistance-salmonella-section\" id=\"a108-jochen-mattner-institute-of-microbiology-amino-acids-colonization-resistance-salmonella\">A108: Jochen Mattner, Institute of Microbiology | Amino acids, colonization resistance, Salmonella<\/button><\/h2><div id=\"a108-jochen-mattner-institute-of-microbiology-amino-acids-colonization-resistance-salmonella-section\" class=\"accordion-body \" aria-labelledby=\"a108-jochen-mattner-institute-of-microbiology-amino-acids-colonization-resistance-salmonella\" role=\"region\" name=\"a108-jochen-mattner-institute-of-microbiology-amino-acids-colonization-resistance-salmonella\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.04.2026 &#8211; 30.09.2028<\/p>\n\n\n\n<p>Amino acids such as arginine and proline influence the immune system as well as different microbial organisms. However, the influence of both amino acids on immune defense and microbiota-mediated colonization resistance or on Salmonella virulence is unknown. Therefore, we will characterize a) the influence of arginine-dependent microbiota on Salmonella infections and b) the role of proline in Salmonella virulence and anti-bacterial immune response.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><div class=\"image-wrapper\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2026\/03\/Mattner2-794x1024.jpg\" alt=\"\" class=\"wp-image-131068 tall-image\" style=\"aspect-ratio:0.775410861703264\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2026\/03\/Mattner2-794x1024.jpg 794w, https:\/\/www.izkf.med.fau.de\/files\/2026\/03\/Mattner2-233x300.jpg 233w, https:\/\/www.izkf.med.fau.de\/files\/2026\/03\/Mattner2-768x990.jpg 768w, https:\/\/www.izkf.med.fau.de\/files\/2026\/03\/Mattner2-1192x1536.jpg 1192w, https:\/\/www.izkf.med.fau.de\/files\/2026\/03\/Mattner2-1589x2048.jpg 1589w, https:\/\/www.izkf.med.fau.de\/files\/2026\/03\/Mattner2-47x60.jpg 47w, https:\/\/www.izkf.med.fau.de\/files\/2026\/03\/Mattner2-186x240.jpg 186w, https:\/\/www.izkf.med.fau.de\/files\/2026\/03\/Mattner2-248x320.jpg 248w, https:\/\/www.izkf.med.fau.de\/files\/2026\/03\/Mattner2-365x470.jpg 365w, https:\/\/www.izkf.med.fau.de\/files\/2026\/03\/Mattner2-scaled.jpg 1986w\" \/><button class=\"image-fullscreen-btn\" onclick=\"openImageFullscreen('https:\/\/www.izkf.med.fau.de\/files\/2026\/03\/Mattner2-scaled.jpg')\">\u26f6<\/button><\/div><figcaption class=\"wp-element-caption\"><strong>Principal Investigator<\/strong><br>Institute of Microbiology<br>E-Mail: jochen.mattner@uk-erlangen.de<\/figcaption><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"a110-fabian-mueller-department-of-medicine-5-raja-atreya-department-of-medicine-1-b-zell-charakterisierung-bei-colitis-ulcerosa\" data-href=\"#a110-fabian-mueller-department-of-medicine-5-raja-atreya-department-of-medicine-1-b-zell-charakterisierung-bei-colitis-ulcerosa\" type=\"button\" aria-expanded=\"false\" aria-controls=\"a110-fabian-mueller-department-of-medicine-5-raja-atreya-department-of-medicine-1-b-zell-charakterisierung-bei-colitis-ulcerosa-section\" id=\"a110-fabian-mueller-department-of-medicine-5-raja-atreya-department-of-medicine-1-b-zell-charakterisierung-bei-colitis-ulcerosa\">A110: Fabian M\u00fcller, Department of Medicine 5 | Raja Atreya, Department of Medicine 1 | B-Zell Charakterisierung bei Colitis ulcerosa<\/button><\/h2><div id=\"a110-fabian-mueller-department-of-medicine-5-raja-atreya-department-of-medicine-1-b-zell-charakterisierung-bei-colitis-ulcerosa-section\" class=\"accordion-body \" aria-labelledby=\"a110-fabian-mueller-department-of-medicine-5-raja-atreya-department-of-medicine-1-b-zell-charakterisierung-bei-colitis-ulcerosa\" role=\"region\" name=\"a110-fabian-mueller-department-of-medicine-5-raja-atreya-department-of-medicine-1-b-zell-charakterisierung-bei-colitis-ulcerosa\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: 01.01.2026 &#8211; 30.06.2028<\/p>\n\n\n\n<p>Intestinal B cells, including plasmablasts are potentially involved in the pathogenesis of ulcerative colitis (UC), as their elevated mucosal presence has recently been described in resistant disease courses. Based on own findings of a successful CD19 CAR T cell treatment in a patient with refractory UC, we aim to characterize the role of gut B cells in perpetuating the inflammatory process and to understand the therapeutic potential of depleting specific B cell subsets in UC.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><\/td><td><\/td><\/tr><tr><td><strong><strong>Principal Investigator<\/strong><\/strong><br>Prof. Dr. Fabian M\u00fcller<br>E-Mail: fabian.mueller@uk-erlangen.de<\/td><td><strong><strong>Principal Investigator<\/strong><br><\/strong>Prof. Dr. Raja Atreya<br>E-Mail: raja.atreya@uk-erlangen.de<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"panel_7e2b66b2\" data-href=\"#panel_7e2b66b2\" type=\"button\" aria-expanded=\"false\" aria-controls=\"panel_7e2b66b2-section\" id=\"panel_7e2b66b2\">A111: David V\u00f6hringer, Department of Infection Biology | Falk Nimmerjahn, Chair of Genetics | Macrophages in allergic asthma<\/button><\/h2><div id=\"panel_7e2b66b2-section\" class=\"accordion-body \" aria-labelledby=\"panel_7e2b66b2\" role=\"region\" name=\"panel_7e2b66b2\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: Not started yet<\/p>\n\n\n\n<p>Allergic asthma (AA) is an inflammatory lung disease. At present it is unclear how macrophage populations in the lung are altered at different stages of allergic inflammation (onset, acute phase, resolution). We will use a mouse AA model to address the population dynamics of macrophages using fate mapping mice, interrogate the role of IL-4\/IL-13 and activating or inhibitory Fc receptors, and study the impact of macrophages on their tissue environment with mouse and human lung organoids<\/p>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"panel_6765ff11\" data-href=\"#panel_6765ff11\" type=\"button\" aria-expanded=\"false\" aria-controls=\"panel_6765ff11-section\" id=\"panel_6765ff11\">A112: Sebastian Zundler, Department of Medicine 1 | Frederik Graw, Department of Medicine 5 | Kinetics of T cell trafficking<\/button><\/h2><div id=\"panel_6765ff11-section\" class=\"accordion-body \" aria-labelledby=\"panel_6765ff11\" role=\"region\" name=\"panel_6765ff11\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: not started yet<\/p>\n\n\n\n<p>T cells are a main driver of inflammatory bowel disease, but the dynamics of their trafficking to and from the gut are incompletely understood. Our project combines unique trafficking models with innovative mathematical approaches to determine and manipulate the kinetics of T cell trafficking in chronic intestinal inflammation. In the long-term perspective, this might lead to improved therapeutic strategies in IBD.<\/p>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"panel_e7afe8ab\" data-href=\"#panel_e7afe8ab\" type=\"button\" aria-expanded=\"false\" aria-controls=\"panel_e7afe8ab-section\" id=\"panel_e7afe8ab\">A109: Dirk Mielenz, Department of Translational Immunology | Ulrike Steffen, Department of Medicine 3 | ER stress and sialylation in plasma cell fate<\/button><\/h2><div id=\"panel_e7afe8ab-section\" class=\"accordion-body \" aria-labelledby=\"panel_e7afe8ab\" role=\"region\" name=\"panel_e7afe8ab\"><div class=\"accordion-inner clearfix\">\n\n<p>Term: Not started yet<\/p>\n\n\n\n<p>We found in mice and humans a plasma cell population with high surface sialylation. We hypothesize that this population represents activated plasma cells that experience ER stress and await survival signals. We will characterize these cells in mice and humans regarding ER stress, survival, signalling and metabolism, analyse plasma cells from mice with B cell intrinsic elevated ER stress, investigate niche support and how surface sialylation influences plasmablast\/ plasma cell fate.<\/p>\n\n<\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-rrze-elements-collapse \"><div class=\"accordion-group \"><h2 class=\"accordion-heading\"><button class=\"accordion-toggle\" data-toggle=\"collapse\" data-name=\"panel_35d97e60\" data-href=\"#panel_35d97e60\" type=\"button\" aria-expanded=\"false\" aria-controls=\"panel_35d97e60-section\" id=\"panel_35d97e60\">A107: Aline Bozec, Department of Medicine 3 | Estrogen Receptor Signaling in B Cells<\/button><\/h2><div id=\"panel_35d97e60-section\" class=\"accordion-body \" aria-labelledby=\"panel_35d97e60\" role=\"region\" name=\"panel_35d97e60\"><div class=\"accordion-inner clearfix\">\n<div class=\"alert clearfix clear alert-success \" title=\"\">\n\n<p>Term: Not started yet<\/p>\n\n<\/div>\n\n\n\n\n\n\n<p>This project investigates the role of estrogen receptor (ER) signaling in B cell activation and metabolic reprogramming in male and female mice. Since women have a higher incidence of autoimmune diseases like rheumatoid arthritis, the impact of ER\u03b1 and ER\u03b2 on B cell proliferation, antibody class switching, and arthritis development is analyzed. Using RNA sequencing, flow cytometry, and metabolic assays, the study aims to uncover sex-specific differences and potential therapeutic targets.<\/p>\n\n\n<div class=\"faudir\">\r\n         <div class=\"format-compact\">\r\n        \r\n                <section class=\"format-compact-container\" aria-labelledby=\"section-title-8609748-2176\" itemscope itemtype=\"https:\/\/schema.org\/Person\">\r\n                                            <div class=\"profile-image-section\"> \r\n                            <figure class=\"signature\"><span class=\"text\">AB<\/span><\/figure>                        <\/div>\r\n                                            <header class=\"profile-header\">\r\n                       <h1 id=\"section-title-8609748-2176\"><span class=\"displayname\" itemprop=\"name\"><abbr title=\"Professor Doctor\" itemprop=\"honorificPrefix\">Prof. Dr.<\/abbr> <span class=\"namepart\"><span itemprop=\"givenName\">Aline<\/span> <span itemprop=\"familyName\">Bozec<\/span><\/span><\/span><\/h1><p class=\"organisation_name\"><span class=\"organization\" itemprop=\"name\">Professorship for Experimental Immunotherapy<\/span><\/p>                \r\n                     <\/header>\r\n                     <div class=\"profile-details\">   \r\n                        <div class=\"profile-contact\"><h2 class=\"contact-title\">Contact<\/h2><ul class=\"icon list-icons\"><li class=\"email listcontent\"><span class=\"value\"><span class=\"screen-reader-text\">Email: <\/span><a itemprop=\"email\" href=\"mailto:aline.bozec@fau.de\">aline.bozec@fau.de<\/a><\/span><\/li><\/ul><\/div>                 <\/div>\r\n                <\/section>    \r\n                <\/div>\r\n\r\n<\/div>\n<\/div><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1355,"featured_media":0,"parent":6778,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"page-templates\/page-subnav.php","meta":{"_rrze_cache":"enabled","_access_permission":"","_rrze_multilang_single_locale":"en_GB","_rrze_multilang_single_source":"https:\/\/www.izkf.med.fau.de\/?page_id=574","footnotes":""},"page_category":[154],"page_tag":[],"workflow_usergroup":[],"class_list":["post-6805","page","type-page","status-publish","hentry","page_category-general","en-GB"],"_links":{"self":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/6805","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/users\/1355"}],"replies":[{"embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/comments?post=6805"}],"version-history":[{"count":11,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/6805\/revisions"}],"predecessor-version":[{"id":134253,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/6805\/revisions\/134253"}],"up":[{"embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/6778"}],"wp:attachment":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/media?parent=6805"}],"wp:term":[{"taxonomy":"page_category","embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/page_category?post=6805"},{"taxonomy":"page_tag","embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/page_tag?post=6805"},{"taxonomy":"workflow_usergroup","embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/workflow_usergroup?post=6805"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}