{"id":21541,"date":"2023-12-11T14:31:04","date_gmt":"2023-12-11T13:31:04","guid":{"rendered":"https:\/\/www.izkf.med.fau.de\/?page_id=21541"},"modified":"2025-10-17T12:35:12","modified_gmt":"2025-10-17T10:35:12","slug":"n11-erbb2-in-der-sclc-immunantwort","status":"publish","type":"page","link":"https:\/\/www.izkf.med.fau.de\/en\/projekte\/jochen-kalden-foerderprogramm\/n11-erbb2-in-der-sclc-immunantwort\/","title":{"rendered":"N11 ERBB2 in SCLC immune response (Meder)"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Deciphering ERBB2 dependent immune regulation in small cell lung cancer (SCLC)<\/h4>\n\n\n\n<p>Term: 01.04.2024 &#8211; 31.03.2027<\/p>\n\n\n\n<p>My preliminary results suggest that ERBB2 is upregulated in SCLC during metastasis and resistance to immune checkpoint blockade (ICB), helping the tumor to escape the immune system. We plan to investigate ERBB2 inhibitors regarding their immunoregulatory properties ex vivo in precision cut tissue slices (PCTS) and in a SCLC mouse model. We will elucidate the underlying molecular mechanisms downstream of ERBB2 and identify patients who may benefit from an ERBB2 targeted therapy.<\/p>\n\n\n\n<p>&nbsp;<\/p>\n\n\n<div class=\"fau-person thumb-size-small border\" itemscope itemtype=\"http:\/\/schema.org\/Person\">\n<div class=\"row\"><figure itemprop=\"image\" class=\"person-thumb\" aria-hidden=\"true\" role=\"presentation\" itemtype=\"http:\/\/schema.org\/ImageObject\"><a href=\"https:\/\/www.izkf.med.fau.de\/person\/prof-dr-lydia-meder\/\" tabindex=\"-1\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/12\/Meder-120x160.jpg\" itemprop=\"contentUrl\" alt=\"Prof. Dr. Lydia Meder\" srcset=\"https:\/\/www.izkf.med.fau.de\/files\/2023\/12\/Meder-120x160.jpg 120w, https:\/\/www.izkf.med.fau.de\/files\/2023\/12\/Meder-240x320.jpg 240w\"><\/a><meta itemprop=\"identifier\" content=\"https:\/\/www.izkf.med.fau.de\/person\/prof-dr-lydia-meder\/\"><meta itemprop=\"width\" content=\"120\"><meta itemprop=\"height\" content=\"160\"><\/figure><div class=\"person-default-thumb\"><h3><a href=\"https:\/\/www.izkf.med.fau.de\/person\/prof-dr-lydia-meder\/\"><span itemprop=\"name\"><span itemprop=\"honorificPrefix\">Prof. Dr.<\/span> <span class=\"fullname\"><span itemprop=\"givenName\">Lydia<\/span> <span itemprop=\"familyName\">Meder<\/span><\/span><\/span><\/a><\/h3><div class=\"person-info\"><ul class=\"contactlist\"><li class=\"person-info-email email\"><span class=\"screen-reader-text\">E-Mail: <\/span><a itemprop=\"email\" href=\"mailto:lydia.meder@fau.de\">lydia.meder@fau.de<\/a><\/li><\/ul><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Deciphering ERBB2 dependent immune regulation in small cell lung cancer (SCLC) Term: 01.04.2024 &#8211; 31.03.2027 My preliminary results suggest that ERBB2 is upregulated in SCLC during metastasis and resistance to immune checkpoint blockade (ICB), helping the tumor to escape the immune system. We plan to investigate ERBB2 inhibitors regarding their immunoregulatory properties ex vivo in [&hellip;]<\/p>\n","protected":false},"author":1355,"featured_media":0,"parent":6825,"menu_order":11,"comment_status":"closed","ping_status":"closed","template":"page-templates\/page-subnav.php","meta":{"_rrze_cache":"enabled","_access_permission":"","_rrze_multilang_single_locale":"en_GB","_rrze_multilang_single_source":"https:\/\/www.izkf.med.fau.de\/?page_id=21535","footnotes":""},"page_category":[],"page_tag":[],"workflow_usergroup":[],"class_list":["post-21541","page","type-page","status-publish","hentry","en-GB"],"_links":{"self":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/21541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/users\/1355"}],"replies":[{"embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/comments?post=21541"}],"version-history":[{"count":4,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/21541\/revisions"}],"predecessor-version":[{"id":114041,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/21541\/revisions\/114041"}],"up":[{"embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/pages\/6825"}],"wp:attachment":[{"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/media?parent=21541"}],"wp:term":[{"taxonomy":"page_category","embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/page_category?post=21541"},{"taxonomy":"page_tag","embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/page_tag?post=21541"},{"taxonomy":"workflow_usergroup","embeddable":true,"href":"https:\/\/www.izkf.med.fau.de\/wp-json\/wp\/v2\/workflow_usergroup?post=21541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}