• Skip navigation
  • Skip to navigation
  • Skip to the bottom
Simulate organization breadcrumb open Simulate organization breadcrumb close
Interdisciplinary Center for Clinical Research
  • FAUTo the central FAU website
  1. Friedrich-Alexander-Universität
  2. Medizinische Fakultät
Suche öffnen
  • Deutsch
  • Uniklinikum Erlangen
  • Life@FAU
  • IZKF und ELAN Antragstool
  1. Friedrich-Alexander-Universität
  2. Medizinische Fakultät

Interdisciplinary Center for Clinical Research

Navigation Navigation close
  • IZKF
    • Structure
    • Committees
    • IZKF Administrative Office
    • Other IZKF
    • Releases
    Portal IZKF Erlangen
  • IZKF funding
    • Advanced Projects
    • Jochen-Kalden-Funding Programme
    • Junior Projects
    Portal IZKF funding
  • Programmes Junior Scientists
    • Clinician Scientist Programme
    • Laboratory Rotations
    • PostDoc-Programme
    • MD-Thesis Scholarships
    • IZKF Research Training Group
    • IZKF Publication Award for Young Scientists
    Portal Karriereförderung Nachwuchs
  • Start Up Funding
    • Do I(I)T
    Portal Funding programmes (Pilot/Synergy)
  • Scientific Events
    • Visiting Professor Programme
    • IZKF-Symposium
    Portal Scientific Events
  • Central projects
    • Special programmes
    Portal Central projects
  1. Home
  2. IZKF funding
  3. Junior Projects
  4. Current Projects
  5. Infection and Immunology

Infection and Immunology

In page navigation: IZKF funding
  • Advanced Projects
  • Jochen-Kalden-Funding Programme
  • Junior Projects
    • Application procedure
    • Current Projects
      • Infection and Immunology
      • Oncology
      • Neurosciences
      • Renal and Vascular Research
      • Further projects
      • Archive Junior Projects
    • Project Handling

Infection and Immunology

Main Research: Immunology and Infection

Term: 01.11.2023 – 30.04.2026

T cells play a key role in IBD, but the impact of Stat5 in CD4+ T cells for chronic colitis is unclear so far. Based on preliminary data demonstrating spontaneous chronic colitis in conditional Stat5 KO mice and decreased Stat5 expression in IBD, I hypothesize that Stat5 in CD4+ T cells counteracts colitis. Thus, in this project, I will explore the mechanisms and effects of CD4-specific Stat5 signalling for experimental colitis and IBD, aiming to identify novel approaches for future therapy.

Tanja Müller

Dr. Tanja Müller

Medizinische Klinik 1

  • E-Mail: tanja.mueller@uk-erlangen.de

Main Research: Immunology and Infection

Term: 01.10.2023 – 31.03.2026

The secretion of correctly glycosylated protective antibodies by long-lived plasma cells is essential for our immune protection. To survive and produce antibodies, long-lived plasma cells require an optimized metabolism. The aim of this study is to determine whether the glucose transporter GLUT1 plays a role in the metabolism of long-lived plasma cells and the functionality of their antibodies. Therefore, we will study a GLUT1-deficient mouse model and patients with GLUT1-deficiency syndrome.

Katharina Pracht

Dr. Katharina Pracht

Molekular-Immunologische Abteilung

  • E-Mail: katharina.pracht@uk-erlangen.de

Main Research: Immunology and Infection

Term: 01.09.2023 – 28.02.2026

To date, it is still obscure why in some patients with psoriasis the autoimmune process is restrained to the skin, whereas in other it extends to the joints. We will adopt models resembling psoriasis and psoriatic arthritis, with the aim of studying the joint involvement secondary to skin inflammation. The comprehension and characterization of the underlying mechanisms involved in the “skin-joint axis” is pivotal for a better understanding of the link between physical barriers and autoimmunity.

Maria Gabriella Raimondo

Dr. Maria Gabriella Raimondo

Medizinische Klinik 3

  • E-Mail: mariagabriella.raimondo@uk-erlangen.de

Main Research: Immunology and Infection

Term: 01.01.2024 – 31.08.2026 (bonus time until 28.02.2027)

PU.1 controls the transcriptional network of matrix production in fibrotic fibroblasts. We have now found that PU.1 is also expressed in matrix-producing osteoblasts. In this proposal, we aim to study the PU.1 network in biopsies from patients with osteoproliferative arthritis by imaging mass cytometry, to dissect PU.1-driven transcription in human osteoblastogenic cultures by ATTAC/CHIP/RNA-seq, and to use a novel osteoblast-targeting PU.1 inhibitor in experimental osteoproliferative arthritis.

Simon Rauber

Dr. Simon Rauber

Medizinische Klinik 3

  • E-Mail: simon.rauber@uk-erlangen.de

Main Research: Immunology and Infection

Term: 01.01.2024 – 30.06.2026

This project aims at identifying the expression of the CFTR complex and functionally characterising its role in in peripheral blood mononuclear cells in the context of Cystic Fibrosis (CF). Moreover, the effects of a CFTR-modulating therapy with Elexacaftor – Tezacaftor – Ivacaftor (ETI) on immune cell function and regulation will be examined in a CFTR knock-out cell line and a CF pig model as well as primary patient-derived cells.

Dr. Alexander Schnell

Dr. Alexander Schnell

  • E-Mail: alexander.schnell@uk-erlangen.de

Schwerpunkt: Infektionsforschung und Immunologie

Term: 01.11.2024 – 30.04.2027

Various factors contribute to the pathogenesis of ulcerative colitis (UC). Importantly, telomere shortening is often observed in intestinal epithelial cells (IECs) of patients with UC. Nevertheless, the functional role telomere length in IECs is poorly understood. This project aims to evaluate how telomere length is involved in the regulation of pro-inflammatory pathways and affects the barrier integrity in patients with UC.

Oana-Maria Thoma

Dr. Oana-Maria Thoma

Medizinische Klinik 1

  • E-Mail: oana-maria.thoma@uk-erlangen.de
Universitätsklinikum Erlangen
IZKF-Geschäftsstelle

Krankenhausstr. 12
91054 Erlangen
  • Download-Center
  • Termine
  • Kontakt
  • Impressum
  • Datenschutz
  • Facebook
  • RSS Feed
  • Twitter
  • Xing
Up